Increased connectivity of hub networks and cognitive impairment in multiple sclerosis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To investigate default-mode network (DMN) and frontoparietal network (FPN) dysfunction in cognitively impaired (CI) patients with multiple sclerosis (MS) because these networks strongly relate to cognition and contain most of the hubs of the brain. Methods: Resting-state fMRI and neuropsychological assessments were performed in 322 patients with MS and 96 healthy controls (HCs). Patients with MS were classified as CI (z score ,22.0 on at least 2 tests; n 5 87), mildly cognitively impaired (z score,21.5 on at least 2 tests and not CI; n 5 65), and cognitively preserved (CP; n 5 180). Within-network connectivity, connectivity with the rest of the brain, and between-network connectivity were calculated and compared between groups. Connectivity values were normalized for individual means and SDs. Results: Only in CI, both the DMN and FPN showed increased connectivity with the rest of the brain compared to HCs and CP, with no change in within- or between-network connectivity. Regionally, this increased connectivity was driven by the inferior parietal, posterior cingulate, and angular gyri. Increased connectivity with the rest of the brain correlated with worse cognitive performance, namely attention for the FPN as well as information processing speed and working memory for both networks. Conclusions: In CI patients with MS, the DMN and FPN showed increased connectivity with the rest of the brain, while normal within- and between-network connectivity levels were maintained. These findings indicate that cognitive impairment in MS features disturbed communication of hub-rich networks, but only with the more peripheral (i.e., nonhub) regions of the brain.

Original languageEnglish
Pages (from-to)2107-2114
Number of pages8
JournalNeurology
Volume88
Issue number22
DOIs
Publication statusPublished - 30 May 2017

Cite this

@article{b0dddc1eefb045e591f21363ac852a2e,
title = "Increased connectivity of hub networks and cognitive impairment in multiple sclerosis",
abstract = "Objective: To investigate default-mode network (DMN) and frontoparietal network (FPN) dysfunction in cognitively impaired (CI) patients with multiple sclerosis (MS) because these networks strongly relate to cognition and contain most of the hubs of the brain. Methods: Resting-state fMRI and neuropsychological assessments were performed in 322 patients with MS and 96 healthy controls (HCs). Patients with MS were classified as CI (z score ,22.0 on at least 2 tests; n 5 87), mildly cognitively impaired (z score,21.5 on at least 2 tests and not CI; n 5 65), and cognitively preserved (CP; n 5 180). Within-network connectivity, connectivity with the rest of the brain, and between-network connectivity were calculated and compared between groups. Connectivity values were normalized for individual means and SDs. Results: Only in CI, both the DMN and FPN showed increased connectivity with the rest of the brain compared to HCs and CP, with no change in within- or between-network connectivity. Regionally, this increased connectivity was driven by the inferior parietal, posterior cingulate, and angular gyri. Increased connectivity with the rest of the brain correlated with worse cognitive performance, namely attention for the FPN as well as information processing speed and working memory for both networks. Conclusions: In CI patients with MS, the DMN and FPN showed increased connectivity with the rest of the brain, while normal within- and between-network connectivity levels were maintained. These findings indicate that cognitive impairment in MS features disturbed communication of hub-rich networks, but only with the more peripheral (i.e., nonhub) regions of the brain.",
author = "Meijer, {Kim A.} and Eijlers, {Anand J.C.} and Linda Douw and Uitdehaag, {Bernard M.J.} and Frederik Barkhof and Geurts, {Jeroen J.G.} and Schoonheim, {Menno M.}",
year = "2017",
month = "5",
day = "30",
doi = "10.1212/WNL.0000000000003982",
language = "English",
volume = "88",
pages = "2107--2114",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
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}

Increased connectivity of hub networks and cognitive impairment in multiple sclerosis. / Meijer, Kim A.; Eijlers, Anand J.C.; Douw, Linda; Uitdehaag, Bernard M.J.; Barkhof, Frederik; Geurts, Jeroen J.G.; Schoonheim, Menno M.

In: Neurology, Vol. 88, No. 22, 30.05.2017, p. 2107-2114.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Increased connectivity of hub networks and cognitive impairment in multiple sclerosis

AU - Meijer, Kim A.

AU - Eijlers, Anand J.C.

AU - Douw, Linda

AU - Uitdehaag, Bernard M.J.

AU - Barkhof, Frederik

AU - Geurts, Jeroen J.G.

AU - Schoonheim, Menno M.

PY - 2017/5/30

Y1 - 2017/5/30

N2 - Objective: To investigate default-mode network (DMN) and frontoparietal network (FPN) dysfunction in cognitively impaired (CI) patients with multiple sclerosis (MS) because these networks strongly relate to cognition and contain most of the hubs of the brain. Methods: Resting-state fMRI and neuropsychological assessments were performed in 322 patients with MS and 96 healthy controls (HCs). Patients with MS were classified as CI (z score ,22.0 on at least 2 tests; n 5 87), mildly cognitively impaired (z score,21.5 on at least 2 tests and not CI; n 5 65), and cognitively preserved (CP; n 5 180). Within-network connectivity, connectivity with the rest of the brain, and between-network connectivity were calculated and compared between groups. Connectivity values were normalized for individual means and SDs. Results: Only in CI, both the DMN and FPN showed increased connectivity with the rest of the brain compared to HCs and CP, with no change in within- or between-network connectivity. Regionally, this increased connectivity was driven by the inferior parietal, posterior cingulate, and angular gyri. Increased connectivity with the rest of the brain correlated with worse cognitive performance, namely attention for the FPN as well as information processing speed and working memory for both networks. Conclusions: In CI patients with MS, the DMN and FPN showed increased connectivity with the rest of the brain, while normal within- and between-network connectivity levels were maintained. These findings indicate that cognitive impairment in MS features disturbed communication of hub-rich networks, but only with the more peripheral (i.e., nonhub) regions of the brain.

AB - Objective: To investigate default-mode network (DMN) and frontoparietal network (FPN) dysfunction in cognitively impaired (CI) patients with multiple sclerosis (MS) because these networks strongly relate to cognition and contain most of the hubs of the brain. Methods: Resting-state fMRI and neuropsychological assessments were performed in 322 patients with MS and 96 healthy controls (HCs). Patients with MS were classified as CI (z score ,22.0 on at least 2 tests; n 5 87), mildly cognitively impaired (z score,21.5 on at least 2 tests and not CI; n 5 65), and cognitively preserved (CP; n 5 180). Within-network connectivity, connectivity with the rest of the brain, and between-network connectivity were calculated and compared between groups. Connectivity values were normalized for individual means and SDs. Results: Only in CI, both the DMN and FPN showed increased connectivity with the rest of the brain compared to HCs and CP, with no change in within- or between-network connectivity. Regionally, this increased connectivity was driven by the inferior parietal, posterior cingulate, and angular gyri. Increased connectivity with the rest of the brain correlated with worse cognitive performance, namely attention for the FPN as well as information processing speed and working memory for both networks. Conclusions: In CI patients with MS, the DMN and FPN showed increased connectivity with the rest of the brain, while normal within- and between-network connectivity levels were maintained. These findings indicate that cognitive impairment in MS features disturbed communication of hub-rich networks, but only with the more peripheral (i.e., nonhub) regions of the brain.

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U2 - 10.1212/WNL.0000000000003982

DO - 10.1212/WNL.0000000000003982

M3 - Article

VL - 88

SP - 2107

EP - 2114

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 22

ER -