Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

Janneke A Wilschut; J Dik F Habbema; Scott D Ramsey; Rob Boer; Caspar W N Looman; Marjolein van Ballegooijen

doi:10.1007/s10552-010-9654-y

Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

Janneke A Wilschut, J Dik F Habbema, Scott D Ramsey, Rob Boer, Caspar W N Looman, Marjolein van Ballegooijen

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

OBJECTIVE: It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.

METHODS: We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.

RESULTS: Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4-3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05-1.07). The age trend did not differ significantly between the two groups.

CONCLUSION: Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.

Original language	English
Pages (from-to)	2287-93
Number of pages	7
Journal	CCC. Cancer Causes and Control
Volume	21
Issue number	12
DOIs	https://doi.org/10.1007/s10552-010-9654-y
Publication status	Published - Dec 2010

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10.1007/s10552-010-9654-y

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@article{0c15baa5b15742f0ba2620412fbb6552,

title = "Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis",

abstract = "OBJECTIVE: It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.METHODS: We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.RESULTS: Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4-3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05-1.07). The age trend did not differ significantly between the two groups.CONCLUSION: Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.",

keywords = "Adenoma/epidemiology, Adult, Algorithms, Colorectal Neoplasms/epidemiology, Disease Susceptibility/epidemiology, Family Health, Female, Humans, Male, Medical History Taking, Middle Aged, Prevalence, Risk Factors",

author = "Wilschut, {Janneke A} and Habbema, {J Dik F} and Ramsey, {Scott D} and Rob Boer and Looman, {Caspar W N} and {van Ballegooijen}, Marjolein",

year = "2010",

month = dec,

doi = "10.1007/s10552-010-9654-y",

language = "English",

volume = "21",

pages = "2287--93",

journal = "CCC. Cancer Causes and Control",

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publisher = "Springer Netherlands",

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Increased risk of adenomas in individuals with a family history of colorectal cancer : results of a meta-analysis. / Wilschut, Janneke A; Habbema, J Dik F; Ramsey, Scott D; Boer, Rob; Looman, Caspar W N; van Ballegooijen, Marjolein.

In: CCC. Cancer Causes and Control, Vol. 21, No. 12, 12.2010, p. 2287-93.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Increased risk of adenomas in individuals with a family history of colorectal cancer

T2 - results of a meta-analysis

AU - Wilschut, Janneke A

AU - Habbema, J Dik F

AU - Ramsey, Scott D

AU - Boer, Rob

AU - Looman, Caspar W N

AU - van Ballegooijen, Marjolein

PY - 2010/12

Y1 - 2010/12

N2 - OBJECTIVE: It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.METHODS: We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.RESULTS: Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4-3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05-1.07). The age trend did not differ significantly between the two groups.CONCLUSION: Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.

AB - OBJECTIVE: It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.METHODS: We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.RESULTS: Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4-3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05-1.07). The age trend did not differ significantly between the two groups.CONCLUSION: Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.

KW - Adenoma/epidemiology

KW - Adult

KW - Algorithms

KW - Colorectal Neoplasms/epidemiology

KW - Disease Susceptibility/epidemiology

KW - Family Health

KW - Female

KW - Humans

KW - Male

KW - Medical History Taking

KW - Middle Aged

KW - Prevalence

KW - Risk Factors

U2 - 10.1007/s10552-010-9654-y

DO - 10.1007/s10552-010-9654-y

M3 - Review article

C2 - 20981482

VL - 21

SP - 2287

EP - 2293

JO - CCC. Cancer Causes and Control

JF - CCC. Cancer Causes and Control

SN - 0957-5243

IS - 12

ER -