Toegenomen kans op een beroerte na gebruik van olanzapine of risperidon bij patiënten met dementie

Translated title of the contribution: Increased risk of stroke in use of olanzapine or risperidone in patients with dementia

R. J. Van Marum*, P. A.F. Jansen

*Corresponding author for this work

Research output: Contribution to journalReview articleProfessional


Post-hoc analysis by the pharmaceutical company Eli Lilly of 5 randomised clinical trials concerning the efficacy of olanzapine in patients with dementia, has shown that patients taking olanzapine have a risk of experiencing a cerebrovascular accident which is 3 times higher than patients taking placebo. This increased risk has also been found in patients with dementia who take risperidone. Details concerning this relationship cannot be obtained from the sparse information supplied by the producers of risperidone and olanzapine. The pathophysiological mechanisms by which atypical antipsychotics may lead to cerebrovascular accidents are not well understood. Atypical antipsychotics are often prescribed for conditions in which evidence of the efficacy of this group of medications is lacking. This association between antipsychotics and cerebrovascular accidents emphasises the need for a stricter and evidence-based prescription policy for antipsychotics. In cases of adverse drug reaction, more openness on the part of pharmaceutical companies is desirable.

Translated title of the contributionIncreased risk of stroke in use of olanzapine or risperidone in patients with dementia
Original languageDutch
Pages (from-to)165-167
Number of pages3
JournalNederlands Tijdschrift voor Geneeskunde
Issue number4
Publication statusPublished - 22 Jan 2005
Externally publishedYes

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