Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin

R. G. IJzerman, R. T. De Jongh, M. A.M. Beijk, M. M. Van Weissenbruch, H. A. Delemarre-van De Waal, E. H. Serné, Coen D.A. Stehouwer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: To investigate whether microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function, we investigated skin microvascular function in individuals with increased coronary heart disease (CHD) risk. Materials and methods: Forty-six healthy White individuals aged 30-70 years were studied. Coronary heart disease risk was assessed with the use of the CHD risk score according to the Framingham Heart Study, which is based on the risk factors age, blood pressure, cigarette smoking, total cholesterol, HDL cholesterol and diabetes. Endothelium-dependent and -independent vasodilation in skin were evaluated with laser Doppler after iontophoresis of acetylcholine and sodium nitroprusside. Videomicroscopy was used to measure recruitment of skin capillaries after arterial occlusion. Results: Coronary heart disease risk score (i.e. the 10-year probability of CHD) varied from 1-37%. Microvascular function decreased with increasing quartiles of CHD risk (for acetylcholine-mediated vasodilation: 687, 585, 420 and 326%, P = 0.002; for nitroprusside-mediated vasodilation: 776, 582, 513 and 366%, P = 0.02; for capillary recruitment: 49.9, 44.6, 27.2 and 26.7%, P = 0.001). These trends were similar in men and women (P for interaction > 0.2) and independent of body mass index. Conclusions: Increased CHD risk is associated with an impaired endothelium-dependent vasodilatation and capillary recruitment in skin, suggesting that microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function.

Original languageEnglish
Pages (from-to)536-542
Number of pages7
JournalEuropean Journal of Clinical Investigation
Volume33
Issue number7
DOIs
Publication statusPublished - 1 Jul 2003

Cite this

@article{2d3c481f6aa94745ad37db72814118ba,
title = "Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin",
abstract = "Background: To investigate whether microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function, we investigated skin microvascular function in individuals with increased coronary heart disease (CHD) risk. Materials and methods: Forty-six healthy White individuals aged 30-70 years were studied. Coronary heart disease risk was assessed with the use of the CHD risk score according to the Framingham Heart Study, which is based on the risk factors age, blood pressure, cigarette smoking, total cholesterol, HDL cholesterol and diabetes. Endothelium-dependent and -independent vasodilation in skin were evaluated with laser Doppler after iontophoresis of acetylcholine and sodium nitroprusside. Videomicroscopy was used to measure recruitment of skin capillaries after arterial occlusion. Results: Coronary heart disease risk score (i.e. the 10-year probability of CHD) varied from 1-37{\%}. Microvascular function decreased with increasing quartiles of CHD risk (for acetylcholine-mediated vasodilation: 687, 585, 420 and 326{\%}, P = 0.002; for nitroprusside-mediated vasodilation: 776, 582, 513 and 366{\%}, P = 0.02; for capillary recruitment: 49.9, 44.6, 27.2 and 26.7{\%}, P = 0.001). These trends were similar in men and women (P for interaction > 0.2) and independent of body mass index. Conclusions: Increased CHD risk is associated with an impaired endothelium-dependent vasodilatation and capillary recruitment in skin, suggesting that microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function.",
keywords = "Acetylcholine, Capillaries, Coronary disease, Endothelial function, Microcirculation",
author = "IJzerman, {R. G.} and {De Jongh}, {R. T.} and Beijk, {M. A.M.} and {Van Weissenbruch}, {M. M.} and {Delemarre-van De Waal}, {H. A.} and Sern{\'e}, {E. H.} and Stehouwer, {Coen D.A.}",
year = "2003",
month = "7",
day = "1",
doi = "10.1046/j.1365-2362.2003.01179.x",
language = "English",
volume = "33",
pages = "536--542",
journal = "European Journal of Clinical Investigation",
issn = "0014-2972",
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}

Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin. / IJzerman, R. G.; De Jongh, R. T.; Beijk, M. A.M.; Van Weissenbruch, M. M.; Delemarre-van De Waal, H. A.; Serné, E. H.; Stehouwer, Coen D.A.

In: European Journal of Clinical Investigation, Vol. 33, No. 7, 01.07.2003, p. 536-542.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin

AU - IJzerman, R. G.

AU - De Jongh, R. T.

AU - Beijk, M. A.M.

AU - Van Weissenbruch, M. M.

AU - Delemarre-van De Waal, H. A.

AU - Serné, E. H.

AU - Stehouwer, Coen D.A.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Background: To investigate whether microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function, we investigated skin microvascular function in individuals with increased coronary heart disease (CHD) risk. Materials and methods: Forty-six healthy White individuals aged 30-70 years were studied. Coronary heart disease risk was assessed with the use of the CHD risk score according to the Framingham Heart Study, which is based on the risk factors age, blood pressure, cigarette smoking, total cholesterol, HDL cholesterol and diabetes. Endothelium-dependent and -independent vasodilation in skin were evaluated with laser Doppler after iontophoresis of acetylcholine and sodium nitroprusside. Videomicroscopy was used to measure recruitment of skin capillaries after arterial occlusion. Results: Coronary heart disease risk score (i.e. the 10-year probability of CHD) varied from 1-37%. Microvascular function decreased with increasing quartiles of CHD risk (for acetylcholine-mediated vasodilation: 687, 585, 420 and 326%, P = 0.002; for nitroprusside-mediated vasodilation: 776, 582, 513 and 366%, P = 0.02; for capillary recruitment: 49.9, 44.6, 27.2 and 26.7%, P = 0.001). These trends were similar in men and women (P for interaction > 0.2) and independent of body mass index. Conclusions: Increased CHD risk is associated with an impaired endothelium-dependent vasodilatation and capillary recruitment in skin, suggesting that microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function.

AB - Background: To investigate whether microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function, we investigated skin microvascular function in individuals with increased coronary heart disease (CHD) risk. Materials and methods: Forty-six healthy White individuals aged 30-70 years were studied. Coronary heart disease risk was assessed with the use of the CHD risk score according to the Framingham Heart Study, which is based on the risk factors age, blood pressure, cigarette smoking, total cholesterol, HDL cholesterol and diabetes. Endothelium-dependent and -independent vasodilation in skin were evaluated with laser Doppler after iontophoresis of acetylcholine and sodium nitroprusside. Videomicroscopy was used to measure recruitment of skin capillaries after arterial occlusion. Results: Coronary heart disease risk score (i.e. the 10-year probability of CHD) varied from 1-37%. Microvascular function decreased with increasing quartiles of CHD risk (for acetylcholine-mediated vasodilation: 687, 585, 420 and 326%, P = 0.002; for nitroprusside-mediated vasodilation: 776, 582, 513 and 366%, P = 0.02; for capillary recruitment: 49.9, 44.6, 27.2 and 26.7%, P = 0.001). These trends were similar in men and women (P for interaction > 0.2) and independent of body mass index. Conclusions: Increased CHD risk is associated with an impaired endothelium-dependent vasodilatation and capillary recruitment in skin, suggesting that microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function.

KW - Acetylcholine

KW - Capillaries

KW - Coronary disease

KW - Endothelial function

KW - Microcirculation

UR - http://www.scopus.com/inward/record.url?scp=0037789568&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2362.2003.01179.x

DO - 10.1046/j.1365-2362.2003.01179.x

M3 - Article

VL - 33

SP - 536

EP - 542

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 7

ER -