TY - JOUR
T1 - Infectious myocarditis
T2 - the role of the cardiac vasculature
AU - Woudstra, Linde
AU - Juffermans, Lynda J.M.
AU - van Rossum, Albert C.
AU - Niessen, Hans W.M.
AU - Krijnen, Paul A.J.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Infectious myocarditis is the result of an immune response to a microbial infection of the heart. The blood vessels of the heart, both the intramyocardial microvasculature and the large epicardial coronary arteries, play an important role in the pathogenesis of infectious myocarditis. First of all, in addition to cardiomyocytes, endothelial cells of the cardiac (micro)vasculature are direct targets for infection. Moreover, through the expression of adhesion molecules and antigen presenting Major Histocompatibility Complex molecules, the blood vessels assist in shaping the cellular immune response in infectious myocarditis. In addition, damage and dysfunction of the cardiac (micro)vasculature are associated with thrombus formation as well as aberrant regulation of vascular tone including coronary vasospasm. These in turn can cause cardiac perfusion abnormalities and even myocardial infarction. In this review, we will discuss the role of the cardiac (micro)vasculature in the pathogenesis of infectious myocarditis.
AB - Infectious myocarditis is the result of an immune response to a microbial infection of the heart. The blood vessels of the heart, both the intramyocardial microvasculature and the large epicardial coronary arteries, play an important role in the pathogenesis of infectious myocarditis. First of all, in addition to cardiomyocytes, endothelial cells of the cardiac (micro)vasculature are direct targets for infection. Moreover, through the expression of adhesion molecules and antigen presenting Major Histocompatibility Complex molecules, the blood vessels assist in shaping the cellular immune response in infectious myocarditis. In addition, damage and dysfunction of the cardiac (micro)vasculature are associated with thrombus formation as well as aberrant regulation of vascular tone including coronary vasospasm. These in turn can cause cardiac perfusion abnormalities and even myocardial infarction. In this review, we will discuss the role of the cardiac (micro)vasculature in the pathogenesis of infectious myocarditis.
KW - Endothelial cells
KW - Infection
KW - Myocardial infarction
KW - Myocarditis
KW - Vasculature
UR - http://www.scopus.com/inward/record.url?scp=85043682071&partnerID=8YFLogxK
U2 - 10.1007/s10741-018-9688-x
DO - 10.1007/s10741-018-9688-x
M3 - Review article
C2 - 29536322
AN - SCOPUS:85043682071
VL - 23
SP - 583
EP - 595
JO - Heart Failure Reviews
JF - Heart Failure Reviews
SN - 1382-4147
IS - 4
ER -