Inflammation and stroke: the Leiden 85-Plus Study

E van Exel, J Gussekloo, A J M de Craen, A Bootsma-van der Wiel, M Frölich, R G J Westendorp

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Experimental evidence indicates that interleukin-10 (IL-10) deficiency is associated with the development of cardiovascular and cerebrovascular disease. We analyzed the relation between low IL-10 production levels, history of stroke, and incident fatal stroke.

SUMMARY OF REPORT: All 85-year-old inhabitants of Leiden, Netherlands (n=599) were visited at their place of residence (response rate, 87%). Production levels of the anti-inflammatory cytokine IL-10 were assessed in a whole blood assay whereby lipopolysaccharide was used as a stimulus. Plasma concentrations of C-reactive protein (CRP) were also used as a marker of inflammation. A history of stroke was obtained at baseline (prevalence, 10%). The number of fatal strokes was prospectively obtained for a median follow-up of 2.6 years (incidence, 1.82 per 100 person-years at risk). Subjects with a history of stroke had significantly lower median IL-10 production levels at baseline than subjects without stroke (558 versus 764 pg/mL; P<0.05). They also had significantly higher median CRP concentrations (6 versus 3 mg/L; P<0.05). The odds ratio for a history of stroke increased to 2.30 (95% CI, 1.12 to 4.72) over strata representing decreasing production levels of IL-10. The relative risk for incident fatal stroke was 2.94 (95% CI, 1.01 to 8.53) when we compared subjects with low or intermediate baseline IL-10 production levels to those with high production levels of IL-10.

CONCLUSIONS: Our data support the hypothesis that subjects with low IL-10 production levels have an increased risk of stroke.

Original languageEnglish
Pages (from-to)1135-8
Number of pages4
JournalStroke
Volume33
Issue number4
Publication statusPublished - Apr 2002

Cite this

van Exel, E., Gussekloo, J., de Craen, A. J. M., Bootsma-van der Wiel, A., Frölich, M., & Westendorp, R. G. J. (2002). Inflammation and stroke: the Leiden 85-Plus Study. Stroke, 33(4), 1135-8.
van Exel, E ; Gussekloo, J ; de Craen, A J M ; Bootsma-van der Wiel, A ; Frölich, M ; Westendorp, R G J. / Inflammation and stroke : the Leiden 85-Plus Study. In: Stroke. 2002 ; Vol. 33, No. 4. pp. 1135-8.
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title = "Inflammation and stroke: the Leiden 85-Plus Study",
abstract = "BACKGROUND: Experimental evidence indicates that interleukin-10 (IL-10) deficiency is associated with the development of cardiovascular and cerebrovascular disease. We analyzed the relation between low IL-10 production levels, history of stroke, and incident fatal stroke.SUMMARY OF REPORT: All 85-year-old inhabitants of Leiden, Netherlands (n=599) were visited at their place of residence (response rate, 87{\%}). Production levels of the anti-inflammatory cytokine IL-10 were assessed in a whole blood assay whereby lipopolysaccharide was used as a stimulus. Plasma concentrations of C-reactive protein (CRP) were also used as a marker of inflammation. A history of stroke was obtained at baseline (prevalence, 10{\%}). The number of fatal strokes was prospectively obtained for a median follow-up of 2.6 years (incidence, 1.82 per 100 person-years at risk). Subjects with a history of stroke had significantly lower median IL-10 production levels at baseline than subjects without stroke (558 versus 764 pg/mL; P<0.05). They also had significantly higher median CRP concentrations (6 versus 3 mg/L; P<0.05). The odds ratio for a history of stroke increased to 2.30 (95{\%} CI, 1.12 to 4.72) over strata representing decreasing production levels of IL-10. The relative risk for incident fatal stroke was 2.94 (95{\%} CI, 1.01 to 8.53) when we compared subjects with low or intermediate baseline IL-10 production levels to those with high production levels of IL-10.CONCLUSIONS: Our data support the hypothesis that subjects with low IL-10 production levels have an increased risk of stroke.",
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van Exel, E, Gussekloo, J, de Craen, AJM, Bootsma-van der Wiel, A, Frölich, M & Westendorp, RGJ 2002, 'Inflammation and stroke: the Leiden 85-Plus Study' Stroke, vol. 33, no. 4, pp. 1135-8.

Inflammation and stroke : the Leiden 85-Plus Study. / van Exel, E; Gussekloo, J; de Craen, A J M; Bootsma-van der Wiel, A; Frölich, M; Westendorp, R G J.

In: Stroke, Vol. 33, No. 4, 04.2002, p. 1135-8.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Inflammation and stroke

T2 - the Leiden 85-Plus Study

AU - van Exel, E

AU - Gussekloo, J

AU - de Craen, A J M

AU - Bootsma-van der Wiel, A

AU - Frölich, M

AU - Westendorp, R G J

PY - 2002/4

Y1 - 2002/4

N2 - BACKGROUND: Experimental evidence indicates that interleukin-10 (IL-10) deficiency is associated with the development of cardiovascular and cerebrovascular disease. We analyzed the relation between low IL-10 production levels, history of stroke, and incident fatal stroke.SUMMARY OF REPORT: All 85-year-old inhabitants of Leiden, Netherlands (n=599) were visited at their place of residence (response rate, 87%). Production levels of the anti-inflammatory cytokine IL-10 were assessed in a whole blood assay whereby lipopolysaccharide was used as a stimulus. Plasma concentrations of C-reactive protein (CRP) were also used as a marker of inflammation. A history of stroke was obtained at baseline (prevalence, 10%). The number of fatal strokes was prospectively obtained for a median follow-up of 2.6 years (incidence, 1.82 per 100 person-years at risk). Subjects with a history of stroke had significantly lower median IL-10 production levels at baseline than subjects without stroke (558 versus 764 pg/mL; P<0.05). They also had significantly higher median CRP concentrations (6 versus 3 mg/L; P<0.05). The odds ratio for a history of stroke increased to 2.30 (95% CI, 1.12 to 4.72) over strata representing decreasing production levels of IL-10. The relative risk for incident fatal stroke was 2.94 (95% CI, 1.01 to 8.53) when we compared subjects with low or intermediate baseline IL-10 production levels to those with high production levels of IL-10.CONCLUSIONS: Our data support the hypothesis that subjects with low IL-10 production levels have an increased risk of stroke.

AB - BACKGROUND: Experimental evidence indicates that interleukin-10 (IL-10) deficiency is associated with the development of cardiovascular and cerebrovascular disease. We analyzed the relation between low IL-10 production levels, history of stroke, and incident fatal stroke.SUMMARY OF REPORT: All 85-year-old inhabitants of Leiden, Netherlands (n=599) were visited at their place of residence (response rate, 87%). Production levels of the anti-inflammatory cytokine IL-10 were assessed in a whole blood assay whereby lipopolysaccharide was used as a stimulus. Plasma concentrations of C-reactive protein (CRP) were also used as a marker of inflammation. A history of stroke was obtained at baseline (prevalence, 10%). The number of fatal strokes was prospectively obtained for a median follow-up of 2.6 years (incidence, 1.82 per 100 person-years at risk). Subjects with a history of stroke had significantly lower median IL-10 production levels at baseline than subjects without stroke (558 versus 764 pg/mL; P<0.05). They also had significantly higher median CRP concentrations (6 versus 3 mg/L; P<0.05). The odds ratio for a history of stroke increased to 2.30 (95% CI, 1.12 to 4.72) over strata representing decreasing production levels of IL-10. The relative risk for incident fatal stroke was 2.94 (95% CI, 1.01 to 8.53) when we compared subjects with low or intermediate baseline IL-10 production levels to those with high production levels of IL-10.CONCLUSIONS: Our data support the hypothesis that subjects with low IL-10 production levels have an increased risk of stroke.

KW - Aged

KW - Aged, 80 and over

KW - C-Reactive Protein/analysis

KW - Causality

KW - Comorbidity

KW - Cross-Sectional Studies

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Inflammation/blood

KW - Interleukin-10/blood

KW - Logistic Models

KW - Male

KW - Netherlands/epidemiology

KW - Odds Ratio

KW - Predictive Value of Tests

KW - Prevalence

KW - Prospective Studies

KW - Risk

KW - Risk Assessment

KW - Stroke/blood

KW - Survival Analysis

KW - Tumor Necrosis Factor-alpha/analysis

M3 - Article

VL - 33

SP - 1135

EP - 1138

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 4

ER -

van Exel E, Gussekloo J, de Craen AJM, Bootsma-van der Wiel A, Frölich M, Westendorp RGJ. Inflammation and stroke: the Leiden 85-Plus Study. Stroke. 2002 Apr;33(4):1135-8.