Inflammation and stroke: the Leiden 85-Plus Study

E van Exel, J Gussekloo, A J M de Craen, A Bootsma-van der Wiel, M Frölich, R G J Westendorp

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Abstract

BACKGROUND: Experimental evidence indicates that interleukin-10 (IL-10) deficiency is associated with the development of cardiovascular and cerebrovascular disease. We analyzed the relation between low IL-10 production levels, history of stroke, and incident fatal stroke.

SUMMARY OF REPORT: All 85-year-old inhabitants of Leiden, Netherlands (n=599) were visited at their place of residence (response rate, 87%). Production levels of the anti-inflammatory cytokine IL-10 were assessed in a whole blood assay whereby lipopolysaccharide was used as a stimulus. Plasma concentrations of C-reactive protein (CRP) were also used as a marker of inflammation. A history of stroke was obtained at baseline (prevalence, 10%). The number of fatal strokes was prospectively obtained for a median follow-up of 2.6 years (incidence, 1.82 per 100 person-years at risk). Subjects with a history of stroke had significantly lower median IL-10 production levels at baseline than subjects without stroke (558 versus 764 pg/mL; P<0.05). They also had significantly higher median CRP concentrations (6 versus 3 mg/L; P<0.05). The odds ratio for a history of stroke increased to 2.30 (95% CI, 1.12 to 4.72) over strata representing decreasing production levels of IL-10. The relative risk for incident fatal stroke was 2.94 (95% CI, 1.01 to 8.53) when we compared subjects with low or intermediate baseline IL-10 production levels to those with high production levels of IL-10.

CONCLUSIONS: Our data support the hypothesis that subjects with low IL-10 production levels have an increased risk of stroke.

Original languageEnglish
Pages (from-to)1135-8
Number of pages4
JournalStroke
Volume33
Issue number4
Publication statusPublished - Apr 2002

Cite this

van Exel, E., Gussekloo, J., de Craen, A. J. M., Bootsma-van der Wiel, A., Frölich, M., & Westendorp, R. G. J. (2002). Inflammation and stroke: the Leiden 85-Plus Study. Stroke, 33(4), 1135-8.