Inflammatory markers and depressed mood in older persons: Results from the health, aging and body composition study

Brenda W.J.H. Penninx, Stephen B. Kritchevsky, Kristine Yaffe, Anne B. Newman, Eleanor M. Simonsick, Susan Rubin, Luigi Ferrucci, Tamara Harris, Marco Pahor

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95% confidence interval [CI] = 1.34-4.47) and 2.40 (95% CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.

Original languageEnglish
Pages (from-to)566-572
Number of pages7
JournalBiological Psychiatry
Volume54
Issue number5
DOIs
Publication statusPublished - 1 Sep 2003
Externally publishedYes

Cite this

Penninx, Brenda W.J.H. ; Kritchevsky, Stephen B. ; Yaffe, Kristine ; Newman, Anne B. ; Simonsick, Eleanor M. ; Rubin, Susan ; Ferrucci, Luigi ; Harris, Tamara ; Pahor, Marco. / Inflammatory markers and depressed mood in older persons : Results from the health, aging and body composition study. In: Biological Psychiatry. 2003 ; Vol. 54, No. 5. pp. 566-572.
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abstract = "Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95{\%} confidence interval [CI] = 1.34-4.47) and 2.40 (95{\%} CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.",
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Penninx, BWJH, Kritchevsky, SB, Yaffe, K, Newman, AB, Simonsick, EM, Rubin, S, Ferrucci, L, Harris, T & Pahor, M 2003, 'Inflammatory markers and depressed mood in older persons: Results from the health, aging and body composition study' Biological Psychiatry, vol. 54, no. 5, pp. 566-572. https://doi.org/10.1016/S0006-3223(02)01811-5

Inflammatory markers and depressed mood in older persons : Results from the health, aging and body composition study. / Penninx, Brenda W.J.H.; Kritchevsky, Stephen B.; Yaffe, Kristine; Newman, Anne B.; Simonsick, Eleanor M.; Rubin, Susan; Ferrucci, Luigi; Harris, Tamara; Pahor, Marco.

In: Biological Psychiatry, Vol. 54, No. 5, 01.09.2003, p. 566-572.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Inflammatory markers and depressed mood in older persons

T2 - Results from the health, aging and body composition study

AU - Penninx, Brenda W.J.H.

AU - Kritchevsky, Stephen B.

AU - Yaffe, Kristine

AU - Newman, Anne B.

AU - Simonsick, Eleanor M.

AU - Rubin, Susan

AU - Ferrucci, Luigi

AU - Harris, Tamara

AU - Pahor, Marco

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95% confidence interval [CI] = 1.34-4.47) and 2.40 (95% CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.

AB - Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95% confidence interval [CI] = 1.34-4.47) and 2.40 (95% CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.

KW - C-reactive protein

KW - Depression

KW - Inflammation

KW - Interleukin-6

KW - Old age

KW - Tumor necrosis factor α

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