Influence of anatomy and head position on intranasal drug deposition

Paul Merkus*, Fenna A. Ebbens, Barbara Muller, Wytske J. Fokkens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The objective of this study was to determine the influence of individual anatomical differences on intranasal drug deposition. The data of a comparison of seven different administration techniques in ten healthy volunteers was used in this single-blind crossover pilot study. After intranasal administration of a dyed test formulation, endoscopic video imaging was done on seven non-sequential days. The deposition pattern per individual around the head of the middle turbinate was analyzed for each technique and correlated with the individual anatomy. Decreased deposition of dyed test formulation in the target area around the head of the middle turbinate was observed in the presence of minor septal deviations, narrow nasal valve areas, or inferior turbinate hypertrophy; a lateral head position helps to bypass a minor septal deviation. Although results are preliminary, we conclude that anatomy and head position are important factors in the deposition of topical nasal drugs and may be the key to improving individual local nasal (steroid) treatment.

Original languageEnglish
Pages (from-to)827-832
Number of pages6
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume263
Issue number9
DOIs
Publication statusPublished - 1 Sep 2006

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