Influence of different haemodialysis modalities on AGE peptide levels: intradialytic versus long-term results

Anne van Tellingen, Casper G Schalkwijk, Tom Teerlink, Rob Barto, Muriel P C Grooteman, Tjeerd van der Ploeg, Piet M ter Wee, Menso J Nubé

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Peptide-linked degradation products of advanced glycation end products (AGE peptides) accumulate in chronic haemodialysis (HD) patients and may contribute to a number of HD-related long-term complications, such as accelerated atherosclerosis.

METHODS: The influence of a single HD session versus long-term HD on serum AGE peptides was determined. The patients were randomized to HD with a low-flux polysulfone (PS; F 6HPS), a high-flux PS (F 60S), a superflux PS (F 500S), or a superflux cellulose triacetate (CTA; Tricea 150G) dialyzer.

RESULTS: During a single HD session, both AGE peptides and reference peptides decreased significantly (AGE peptides: Tricea 150G -37.0 +/- 2.9%; F 6HPS -35.5 +/- 2.4%; F 60S -39.5 +/- 4.7%, and F 500S -43.3 +/- 2.1%, p = 0.005; reference peptides: Tricea 150G -73.2 +/- 8.8%; F 6HPS -73.2 +/- 7.9%; F 60S -72.5 +/- 8.2%, and F 500S -74.1 +/- 7.3%, p = 0.005). After 12 weeks of HD with the superflux CTA, the AGE peptide levels decreased significantly (week 1: 2.7 +/- 1.1 arbitrary units, week 12: 2.5 +/- 1.2 arbitrary units, decrease 7.4%; p = 0.01), whereas the AGE peptide levels remained unchanged after HD with each of the other three modalities. The reference peptide levels did not change after 12 weeks of HD.

CONCLUSION: Although AGE peptides can be effectively removed during a single HD session, superflux CTA seems to be the only modality capable of reducing AGE peptides in the long term.

Original languageEnglish
Pages (from-to)c1-c7
JournalNephron. Clinical practice
Volume100
Issue number1
DOIs
Publication statusPublished - 2005

Cite this

van Tellingen, A., Schalkwijk, C. G., Teerlink, T., Barto, R., Grooteman, M. P. C., van der Ploeg, T., ... Nubé, M. J. (2005). Influence of different haemodialysis modalities on AGE peptide levels: intradialytic versus long-term results. Nephron. Clinical practice, 100(1), c1-c7. https://doi.org/10.1159/000084106