Inhibitory modulation of neuronal voltage-dependent sodium current by Phe-Met-Arg-Phe-amide

Arjen B. Brussaard; Andries Ter Maat; Theo A. de Vlieger; Karel S. Kits

doi:10.1016/0304-3940(90)90283-F

Inhibitory modulation of neuronal voltage-dependent sodium current by Phe-Met-Arg-Phe-amide

Arjen B. Brussaard, Andries Ter Maat, Theo A. de Vlieger, Karel S. Kits

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The tetrodotoxin (TTX)-sensitive, voltage-gated Na+-current (INa) in a cluster of peptidergic neurons, involved in egg laying, in the CNS of the mollusc Lymnaea stagnalis, is modulated by the neuropeptide FMRFa (Phe-Met-Arg-Phe-NH2). Application of FMRFa reversibly reduced the isolated INa in a dose-dependent fashion. The physiological consequence is that the threshold for action potential generation is increased, causing an arrest of ongoing firing activity. The inhibitory action of FMRFa reported here is the first known example of modulation of the voltage-gated INa by a putative neurotransmitter in intact nerve cells. This finding underlines the importance of modulation of ionic currents as a mechanism of regulation of neuronal excitability and includes the voltage dependent Na current in the range of currents subject to transmitter modulation. © 1990.

Original language	English
Pages (from-to)	325-332
Journal	Neuroscience Letters
Volume	111
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(90)90283-F
Publication status	Published - 6 Apr 1990
Externally published	Yes

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10.1016/0304-3940(90)90283-F

Cite this

@article{43ccbae59886459f98d4bc05d2290384,

title = "Inhibitory modulation of neuronal voltage-dependent sodium current by Phe-Met-Arg-Phe-amide",

abstract = "The tetrodotoxin (TTX)-sensitive, voltage-gated Na+-current (INa) in a cluster of peptidergic neurons, involved in egg laying, in the CNS of the mollusc Lymnaea stagnalis, is modulated by the neuropeptide FMRFa (Phe-Met-Arg-Phe-NH2). Application of FMRFa reversibly reduced the isolated INa in a dose-dependent fashion. The physiological consequence is that the threshold for action potential generation is increased, causing an arrest of ongoing firing activity. The inhibitory action of FMRFa reported here is the first known example of modulation of the voltage-gated INa by a putative neurotransmitter in intact nerve cells. This finding underlines the importance of modulation of ionic currents as a mechanism of regulation of neuronal excitability and includes the voltage dependent Na current in the range of currents subject to transmitter modulation. {\textcopyright} 1990.",

author = "Brussaard, {Arjen B.} and Maat, {Andries Ter} and {de Vlieger}, {Theo A.} and Kits, {Karel S.}",

year = "1990",

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TY - JOUR

T1 - Inhibitory modulation of neuronal voltage-dependent sodium current by Phe-Met-Arg-Phe-amide

AU - Brussaard, Arjen B.

AU - Maat, Andries Ter

AU - de Vlieger, Theo A.

AU - Kits, Karel S.

PY - 1990/4/6

Y1 - 1990/4/6

N2 - The tetrodotoxin (TTX)-sensitive, voltage-gated Na+-current (INa) in a cluster of peptidergic neurons, involved in egg laying, in the CNS of the mollusc Lymnaea stagnalis, is modulated by the neuropeptide FMRFa (Phe-Met-Arg-Phe-NH2). Application of FMRFa reversibly reduced the isolated INa in a dose-dependent fashion. The physiological consequence is that the threshold for action potential generation is increased, causing an arrest of ongoing firing activity. The inhibitory action of FMRFa reported here is the first known example of modulation of the voltage-gated INa by a putative neurotransmitter in intact nerve cells. This finding underlines the importance of modulation of ionic currents as a mechanism of regulation of neuronal excitability and includes the voltage dependent Na current in the range of currents subject to transmitter modulation. © 1990.

AB - The tetrodotoxin (TTX)-sensitive, voltage-gated Na+-current (INa) in a cluster of peptidergic neurons, involved in egg laying, in the CNS of the mollusc Lymnaea stagnalis, is modulated by the neuropeptide FMRFa (Phe-Met-Arg-Phe-NH2). Application of FMRFa reversibly reduced the isolated INa in a dose-dependent fashion. The physiological consequence is that the threshold for action potential generation is increased, causing an arrest of ongoing firing activity. The inhibitory action of FMRFa reported here is the first known example of modulation of the voltage-gated INa by a putative neurotransmitter in intact nerve cells. This finding underlines the importance of modulation of ionic currents as a mechanism of regulation of neuronal excitability and includes the voltage dependent Na current in the range of currents subject to transmitter modulation. © 1990.

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