Initial experience with a prototype dual-crystal (LSO/NaI) dual-head coincidence camera in oncology

Urvi Joshi, Otto S. Hoekstra, Ronald Boellaard, Emile F.I. Comans, Pieter G.H.M. Raijmakers, Rik J. Pijpers, Steven D. Miller, Gerrit J.J. Teule, Arthur Van Lingen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The aim of this study was to evaluate the in vivo performance of a prototype dual-crystal [lutetium oxyorthosilicate (LSO)/sodium iodide (NaI)] dual-head coincidence camera (DHC) for PET and SPET (LSO-PS), in comparison to BGO-PET with fluorine-18 fluorodeoxyglucose (FDG) in oncology. This follows earlier reports that LSO-PS has noise-equivalent counting (NEC) rates comparable to partial ring BGO-PET, i.e. clearly higher than standard NaI DHCs. Twenty-four randomly selected oncological patients referred for whole-body FDG-PET underwent BGO-PET followed by LSO-PS. Four nuclear medicine physicians were randomised to read a single scan modality, in terms of lesion intensity, location and likelihood of malignancy. BGO-PET was considered the gold standard. Forty-eight lesions were classified as positive with BGO-PET, of which LSO-PS identified 73% (95% CI 60-86%). There was good observer agreement for both modalities in terms of intensity, location and interpretation. Lesions were missed by LSO-PS in 13 patients in the chest (n=6), neck (n=3) and abdomen (n=4). The diameter of these lesions was estimated to be 0.5-1 cm. Initial results justify further evaluation of LSO-PS in specific clinical situations, especially if a role as an instrument of triage for PET is foreseen.

Original languageEnglish
Pages (from-to)596-598
Number of pages3
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume31
Issue number4
DOIs
Publication statusPublished - 1 Jan 2004

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