Innate Lymphoid Cells: 10 Years On

Eric Vivier, David Artis, Marco Colonna, Andreas Diefenbach, James P. di Santo, G. rard Eberl, Shigeo Koyasu, Richard M. Locksley, Andrew N. J. McKenzie, Reina E. Mebius, Fiona Powrie, Hergen Spits

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are deeply integrated into the fabric of tissues. The discovery and investigation of ILCs over the past decade has changed our perception of immune regulation and how the immune system contributes to the maintenance of tissue homeostasis. We now know that cytokine-producing ILCs contribute to multiple immune pathways by, for example, sustaining appropriate immune responses to commensals and pathogens at mucosal barriers, potentiating adaptive immunity, and regulating tissue inflammation. Critically, the biology of ILCs also extends beyond classical immunology to metabolic homeostasis, tissue remodeling, and dialog with the nervous system. The last 10 years have also contributed to our greater understanding of the transcriptional networks that regulate lymphocyte commitment and delineation. This, in conjunction with the recent advances in our understanding of the influence of local tissue microenvironments on the plasticity and function of ILCs, has led to a re-evaluation of their existing categorization. In this review, we distill the advances in ILC biology over the past decade to refine the nomenclature of ILCs and highlight the importance of ILCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration. Since the discovery of innate lymphoid cells a decade ago, studies in this field have drastically expanded our understanding of the role of the immune system in the maintenance of homeostasis. This Review explores the immune functions of these cells and their connection to metabolism, tissue repair, and the nervous system.
Original languageEnglish
Pages (from-to)1054-1066
Number of pages13
JournalCell
Volume174
Issue number5
DOIs
Publication statusPublished - 2018

Cite this

Vivier, E., Artis, D., Colonna, M., Diefenbach, A., di Santo, J. P., Eberl, G. R., ... Spits, H. (2018). Innate Lymphoid Cells: 10 Years On. Cell, 174(5), 1054-1066. https://doi.org/10.1016/j.cell.2018.07.017
Vivier, Eric ; Artis, David ; Colonna, Marco ; Diefenbach, Andreas ; di Santo, James P. ; Eberl, G. rard ; Koyasu, Shigeo ; Locksley, Richard M. ; McKenzie, Andrew N. J. ; Mebius, Reina E. ; Powrie, Fiona ; Spits, Hergen. / Innate Lymphoid Cells : 10 Years On. In: Cell. 2018 ; Vol. 174, No. 5. pp. 1054-1066.
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abstract = "Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are deeply integrated into the fabric of tissues. The discovery and investigation of ILCs over the past decade has changed our perception of immune regulation and how the immune system contributes to the maintenance of tissue homeostasis. We now know that cytokine-producing ILCs contribute to multiple immune pathways by, for example, sustaining appropriate immune responses to commensals and pathogens at mucosal barriers, potentiating adaptive immunity, and regulating tissue inflammation. Critically, the biology of ILCs also extends beyond classical immunology to metabolic homeostasis, tissue remodeling, and dialog with the nervous system. The last 10 years have also contributed to our greater understanding of the transcriptional networks that regulate lymphocyte commitment and delineation. This, in conjunction with the recent advances in our understanding of the influence of local tissue microenvironments on the plasticity and function of ILCs, has led to a re-evaluation of their existing categorization. In this review, we distill the advances in ILC biology over the past decade to refine the nomenclature of ILCs and highlight the importance of ILCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration. Since the discovery of innate lymphoid cells a decade ago, studies in this field have drastically expanded our understanding of the role of the immune system in the maintenance of homeostasis. This Review explores the immune functions of these cells and their connection to metabolism, tissue repair, and the nervous system.",
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Vivier, E, Artis, D, Colonna, M, Diefenbach, A, di Santo, JP, Eberl, GR, Koyasu, S, Locksley, RM, McKenzie, ANJ, Mebius, RE, Powrie, F & Spits, H 2018, 'Innate Lymphoid Cells: 10 Years On' Cell, vol. 174, no. 5, pp. 1054-1066. https://doi.org/10.1016/j.cell.2018.07.017

Innate Lymphoid Cells : 10 Years On. / Vivier, Eric; Artis, David; Colonna, Marco; Diefenbach, Andreas; di Santo, James P.; Eberl, G. rard; Koyasu, Shigeo; Locksley, Richard M.; McKenzie, Andrew N. J.; Mebius, Reina E.; Powrie, Fiona; Spits, Hergen.

In: Cell, Vol. 174, No. 5, 2018, p. 1054-1066.

Research output: Contribution to journalReview articleAcademicpeer-review

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T1 - Innate Lymphoid Cells

T2 - 10 Years On

AU - Vivier, Eric

AU - Artis, David

AU - Colonna, Marco

AU - Diefenbach, Andreas

AU - di Santo, James P.

AU - Eberl, G. rard

AU - Koyasu, Shigeo

AU - Locksley, Richard M.

AU - McKenzie, Andrew N. J.

AU - Mebius, Reina E.

AU - Powrie, Fiona

AU - Spits, Hergen

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018

Y1 - 2018

N2 - Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are deeply integrated into the fabric of tissues. The discovery and investigation of ILCs over the past decade has changed our perception of immune regulation and how the immune system contributes to the maintenance of tissue homeostasis. We now know that cytokine-producing ILCs contribute to multiple immune pathways by, for example, sustaining appropriate immune responses to commensals and pathogens at mucosal barriers, potentiating adaptive immunity, and regulating tissue inflammation. Critically, the biology of ILCs also extends beyond classical immunology to metabolic homeostasis, tissue remodeling, and dialog with the nervous system. The last 10 years have also contributed to our greater understanding of the transcriptional networks that regulate lymphocyte commitment and delineation. This, in conjunction with the recent advances in our understanding of the influence of local tissue microenvironments on the plasticity and function of ILCs, has led to a re-evaluation of their existing categorization. In this review, we distill the advances in ILC biology over the past decade to refine the nomenclature of ILCs and highlight the importance of ILCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration. Since the discovery of innate lymphoid cells a decade ago, studies in this field have drastically expanded our understanding of the role of the immune system in the maintenance of homeostasis. This Review explores the immune functions of these cells and their connection to metabolism, tissue repair, and the nervous system.

AB - Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are deeply integrated into the fabric of tissues. The discovery and investigation of ILCs over the past decade has changed our perception of immune regulation and how the immune system contributes to the maintenance of tissue homeostasis. We now know that cytokine-producing ILCs contribute to multiple immune pathways by, for example, sustaining appropriate immune responses to commensals and pathogens at mucosal barriers, potentiating adaptive immunity, and regulating tissue inflammation. Critically, the biology of ILCs also extends beyond classical immunology to metabolic homeostasis, tissue remodeling, and dialog with the nervous system. The last 10 years have also contributed to our greater understanding of the transcriptional networks that regulate lymphocyte commitment and delineation. This, in conjunction with the recent advances in our understanding of the influence of local tissue microenvironments on the plasticity and function of ILCs, has led to a re-evaluation of their existing categorization. In this review, we distill the advances in ILC biology over the past decade to refine the nomenclature of ILCs and highlight the importance of ILCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration. Since the discovery of innate lymphoid cells a decade ago, studies in this field have drastically expanded our understanding of the role of the immune system in the maintenance of homeostasis. This Review explores the immune functions of these cells and their connection to metabolism, tissue repair, and the nervous system.

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Vivier E, Artis D, Colonna M, Diefenbach A, di Santo JP, Eberl GR et al. Innate Lymphoid Cells: 10 Years On. Cell. 2018;174(5):1054-1066. https://doi.org/10.1016/j.cell.2018.07.017