Abstract

Leukocyte function-associated molecule 1 (LFA-1) is an integrin that plays a major role in the immune system. Recent findings demonstrate that LFA-1 has a two-way signaling function, mediating cell adhesion and stimulating intracellular processes at the same time. Here, Marijke Lub, Yvette van Kooyk and Carl Figdor discuss the 'inside-out' and 'outside-in' signaling properties of LFA-1, as a prototype leukocyte integrin, in normal and malignant T cells. They integrate data into a model that highlights the role of the cytoskeleton in the regulation of LFA-1.

Original languageEnglish
Pages (from-to)479-83
Number of pages5
JournalImmunology today
Volume16
Issue number10
Publication statusPublished - Oct 1995

Cite this

Lub, M., van Kooyk, Y., & Figdor, C. G. (1995). Ins and outs of LFA-1. Immunology today, 16(10), 479-83.