Abstract

Leukocyte function-associated molecule 1 (LFA-1) is an integrin that plays a major role in the immune system. Recent findings demonstrate that LFA-1 has a two-way signaling function, mediating cell adhesion and stimulating intracellular processes at the same time. Here, Marijke Lub, Yvette van Kooyk and Carl Figdor discuss the 'inside-out' and 'outside-in' signaling properties of LFA-1, as a prototype leukocyte integrin, in normal and malignant T cells. They integrate data into a model that highlights the role of the cytoskeleton in the regulation of LFA-1.

Original languageEnglish
Pages (from-to)479-83
Number of pages5
JournalImmunology today
Volume16
Issue number10
Publication statusPublished - Oct 1995

Cite this

Lub, M., van Kooyk, Y., & Figdor, C. G. (1995). Ins and outs of LFA-1. Immunology today, 16(10), 479-83.
Lub, M ; van Kooyk, Y ; Figdor, C G. / Ins and outs of LFA-1. In: Immunology today. 1995 ; Vol. 16, No. 10. pp. 479-83.
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title = "Ins and outs of LFA-1",
abstract = "Leukocyte function-associated molecule 1 (LFA-1) is an integrin that plays a major role in the immune system. Recent findings demonstrate that LFA-1 has a two-way signaling function, mediating cell adhesion and stimulating intracellular processes at the same time. Here, Marijke Lub, Yvette van Kooyk and Carl Figdor discuss the 'inside-out' and 'outside-in' signaling properties of LFA-1, as a prototype leukocyte integrin, in normal and malignant T cells. They integrate data into a model that highlights the role of the cytoskeleton in the regulation of LFA-1.",
keywords = "Animals, Cell Adhesion, Humans, Lymphocyte Function-Associated Antigen-1/physiology",
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year = "1995",
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language = "English",
volume = "16",
pages = "479--83",
journal = "Immunology today",
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Lub, M, van Kooyk, Y & Figdor, CG 1995, 'Ins and outs of LFA-1' Immunology today, vol. 16, no. 10, pp. 479-83.

Ins and outs of LFA-1. / Lub, M; van Kooyk, Y; Figdor, C G.

In: Immunology today, Vol. 16, No. 10, 10.1995, p. 479-83.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Ins and outs of LFA-1

AU - Lub, M

AU - van Kooyk, Y

AU - Figdor, C G

PY - 1995/10

Y1 - 1995/10

N2 - Leukocyte function-associated molecule 1 (LFA-1) is an integrin that plays a major role in the immune system. Recent findings demonstrate that LFA-1 has a two-way signaling function, mediating cell adhesion and stimulating intracellular processes at the same time. Here, Marijke Lub, Yvette van Kooyk and Carl Figdor discuss the 'inside-out' and 'outside-in' signaling properties of LFA-1, as a prototype leukocyte integrin, in normal and malignant T cells. They integrate data into a model that highlights the role of the cytoskeleton in the regulation of LFA-1.

AB - Leukocyte function-associated molecule 1 (LFA-1) is an integrin that plays a major role in the immune system. Recent findings demonstrate that LFA-1 has a two-way signaling function, mediating cell adhesion and stimulating intracellular processes at the same time. Here, Marijke Lub, Yvette van Kooyk and Carl Figdor discuss the 'inside-out' and 'outside-in' signaling properties of LFA-1, as a prototype leukocyte integrin, in normal and malignant T cells. They integrate data into a model that highlights the role of the cytoskeleton in the regulation of LFA-1.

KW - Animals

KW - Cell Adhesion

KW - Humans

KW - Lymphocyte Function-Associated Antigen-1/physiology

M3 - Review article

VL - 16

SP - 479

EP - 483

JO - Immunology today

JF - Immunology today

SN - 0167-5699

IS - 10

ER -

Lub M, van Kooyk Y, Figdor CG. Ins and outs of LFA-1. Immunology today. 1995 Oct;16(10):479-83.