Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

Ann Hellström; David Ley; Ingrid Hansen-Pupp; Boubou Hallberg; Chatarina Löfqvist; Linda van Marter; Mirjam van Weissenbruch; Luca A Ramenghi; Kathryn Beardsall; David Dunger; Anna-Lena Hård; Lois E H Smith

doi:10.1111/apa.13350

Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

Ann Hellström, David Ley, Ingrid Hansen-Pupp, Boubou Hallberg, Chatarina Löfqvist, Linda van Marter, Mirjam van Weissenbruch, Luca A Ramenghi, Kathryn Beardsall, David Dunger, Anna-Lena Hård, Lois E H Smith

Pediatric surgery

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.

CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

Original language	English
Pages (from-to)	576-86
Number of pages	11
Journal	Acta Paediatrica
Volume	105
Issue number	6
DOIs	https://doi.org/10.1111/apa.13350
Publication status	Published - Jun 2016

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10.1111/apa.13350

Cite this

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title = "Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development",

abstract = "UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.",

keywords = "Journal Article, Review",

author = "Ann Hellstr{\"o}m and David Ley and Ingrid Hansen-Pupp and Boubou Hallberg and Chatarina L{\"o}fqvist and {van Marter}, Linda and {van Weissenbruch}, Mirjam and Ramenghi, {Luca A} and Kathryn Beardsall and David Dunger and Anna-Lena H{\aa}rd and Smith, {Lois E H}",

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year = "2016",

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doi = "10.1111/apa.13350",

language = "English",

volume = "105",

pages = "576--86",

journal = "Acta Paediatrica",

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T1 - Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

AU - Hellström, Ann

AU - Ley, David

AU - Hansen-Pupp, Ingrid

AU - Hallberg, Boubou

AU - Löfqvist, Chatarina

AU - van Marter, Linda

AU - van Weissenbruch, Mirjam

AU - Ramenghi, Luca A

AU - Beardsall, Kathryn

AU - Dunger, David

AU - Hård, Anna-Lena

AU - Smith, Lois E H

PY - 2016/6

Y1 - 2016/6

N2 - UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

AB - UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

KW - Journal Article

KW - Review

U2 - 10.1111/apa.13350

DO - 10.1111/apa.13350

M3 - Article

C2 - 26833743

VL - 105

SP - 576

EP - 586

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 6

ER -