Insulin-like growth factor axis targeting in cancer and tumour angiogenesis – the missing link

Judy R. van Beijnum, Wietske Pieters, Patrycja Nowak-Sliwinska, Arjan W. Griffioen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Numerous molecular players in the process of tumour angiogenesis have been shown to offer potential for therapeutic targeting. Initially denoted to be involved in malignant transformation and tumour progression, the insulin-like growth factor (IGF) signalling axis has been subject to therapeutic interference, albeit with limited clinical success. More recently, IGFs and their receptors have received attention for their contribution to tumour angiogenesis, which offers novel therapeutic opportunities. Here we review the contribution of this signalling axis to tumour angiogenesis, the mechanisms of resistance to therapy and the interplay with other pro-angiogenic pathways, to offer insight in the renewed interest in the application of IGF axis targeting agents in anti-cancer combination therapies.

Original languageEnglish
Pages (from-to)1755-1768
Number of pages14
JournalBiological Reviews
Volume92
Issue number3
DOIs
Publication statusPublished - 1 Aug 2017

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