Insulin regulates brain function, but how does it get there?

Sarah M Gray, Rick I Meijer, Eugene J Barrett

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

We have learned over the last several decades that the brain is an important target for insulin action. Insulin in the central nervous system (CNS) affects feeding behavior and body energy stores, the metabolism of glucose and fats in the liver and adipose, and various aspects of memory and cognition. Insulin may even influence the development or progression of Alzheimer disease. Yet, a number of seemingly simple questions (e.g., What is the pathway for delivery of insulin to the brain? Is insulin's delivery to the brain mediated by the insulin receptor and is it a regulated process? Is brain insulin delivery affected by insulin resistance?) are unanswered. Here we briefly review accumulated findings affirming the importance of insulin as a CNS regulatory peptide, examine the current understanding of how peripheral insulin is delivered to the brain, and identify key gaps in the current understanding of this process.

Original languageEnglish
Pages (from-to)3992-7
Number of pages6
JournalDiabetes
Volume63
Issue number12
DOIs
Publication statusPublished - Dec 2014

Cite this

Gray, Sarah M ; Meijer, Rick I ; Barrett, Eugene J. / Insulin regulates brain function, but how does it get there?. In: Diabetes. 2014 ; Vol. 63, No. 12. pp. 3992-7.
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title = "Insulin regulates brain function, but how does it get there?",
abstract = "We have learned over the last several decades that the brain is an important target for insulin action. Insulin in the central nervous system (CNS) affects feeding behavior and body energy stores, the metabolism of glucose and fats in the liver and adipose, and various aspects of memory and cognition. Insulin may even influence the development or progression of Alzheimer disease. Yet, a number of seemingly simple questions (e.g., What is the pathway for delivery of insulin to the brain? Is insulin's delivery to the brain mediated by the insulin receptor and is it a regulated process? Is brain insulin delivery affected by insulin resistance?) are unanswered. Here we briefly review accumulated findings affirming the importance of insulin as a CNS regulatory peptide, examine the current understanding of how peripheral insulin is delivered to the brain, and identify key gaps in the current understanding of this process.",
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Insulin regulates brain function, but how does it get there? / Gray, Sarah M; Meijer, Rick I; Barrett, Eugene J.

In: Diabetes, Vol. 63, No. 12, 12.2014, p. 3992-7.

Research output: Contribution to journalReview articleAcademicpeer-review

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T1 - Insulin regulates brain function, but how does it get there?

AU - Gray, Sarah M

AU - Meijer, Rick I

AU - Barrett, Eugene J

N1 - © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

PY - 2014/12

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N2 - We have learned over the last several decades that the brain is an important target for insulin action. Insulin in the central nervous system (CNS) affects feeding behavior and body energy stores, the metabolism of glucose and fats in the liver and adipose, and various aspects of memory and cognition. Insulin may even influence the development or progression of Alzheimer disease. Yet, a number of seemingly simple questions (e.g., What is the pathway for delivery of insulin to the brain? Is insulin's delivery to the brain mediated by the insulin receptor and is it a regulated process? Is brain insulin delivery affected by insulin resistance?) are unanswered. Here we briefly review accumulated findings affirming the importance of insulin as a CNS regulatory peptide, examine the current understanding of how peripheral insulin is delivered to the brain, and identify key gaps in the current understanding of this process.

AB - We have learned over the last several decades that the brain is an important target for insulin action. Insulin in the central nervous system (CNS) affects feeding behavior and body energy stores, the metabolism of glucose and fats in the liver and adipose, and various aspects of memory and cognition. Insulin may even influence the development or progression of Alzheimer disease. Yet, a number of seemingly simple questions (e.g., What is the pathway for delivery of insulin to the brain? Is insulin's delivery to the brain mediated by the insulin receptor and is it a regulated process? Is brain insulin delivery affected by insulin resistance?) are unanswered. Here we briefly review accumulated findings affirming the importance of insulin as a CNS regulatory peptide, examine the current understanding of how peripheral insulin is delivered to the brain, and identify key gaps in the current understanding of this process.

KW - Brain/metabolism

KW - Cerebrospinal Fluid/metabolism

KW - Glucose/metabolism

KW - Glucose Transport Proteins, Facilitative/metabolism

KW - Glucose Transporter Type 4/metabolism

KW - Humans

KW - Insulin/metabolism

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