Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of A Nonrandomized Prospective Study Using A Standardized Follow-Up Program

M.R. Vergeer; P.A.H. Doornaert; D.H.F. Rietveld; C.R. Leemans; B.J. Slotman; J.A. Langendijk

doi:10.1016/j.ijrobp.2008.07.059

Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of A Nonrandomized Prospective Study Using A Standardized Follow-Up Program

M.R. Vergeer, P.A.H. Doornaert, D.H.F. Rietveld, C.R. Leemans, B.J. Slotman, J.A. Langendijk

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: The purpose of this study was to compare intensity-modulated radiation therapy (IMRT) and three-dimensional conventional radiotherapy (3D-CRT) with regard to patient-rated xerostomia, Radiation Therapy Oncology G roup (RTOG) acute and late xerostomia and health-related quality of life (HRQoL) among patients with head and neck squamous cell carcinoma (HNSCC). Methods and Materials: Included were 241 patients with HNSCC treated with bilateral irradiation +/- chemotherapy. Since 2000, all patients treated with HNSCC were included in a program, which prospectively assessed acute and late morbidity according to the RTOG and HRQoL on a routine basis at regular intervals. Before October 2004, all patients were treated with 3D-CRT (N = 150). After clinical implementation in October 2004, 91 patients received IMRT. In this study, the differences regarding RTOG toxicity, xerostomia, and other items of HRQoL were analyzed. Results: The use of IMRT resulted in a significant reduction of the mean dose of the parotid glands (27 Gy vs. 43 Gy (p

Original language	Undefined/Unknown
Pages (from-to)	1-8
Journal	International journal of radiation oncology, biology, physics
Volume	74
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2008.07.059
Publication status	Published - 2009

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10.1016/j.ijrobp.2008.07.059

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Vergeer, M. R., Doornaert, P. A. H., Rietveld, D. H. F., Leemans, C. R., Slotman, B. J., & Langendijk, J. A. (2009). Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of A Nonrandomized Prospective Study Using A Standardized Follow-Up Program. International journal of radiation oncology, biology, physics, 74(1), 1-8. https://doi.org/10.1016/j.ijrobp.2008.07.059

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title = "Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of A Nonrandomized Prospective Study Using A Standardized Follow-Up Program",

abstract = "Purpose: The purpose of this study was to compare intensity-modulated radiation therapy (IMRT) and three-dimensional conventional radiotherapy (3D-CRT) with regard to patient-rated xerostomia, Radiation Therapy Oncology G roup (RTOG) acute and late xerostomia and health-related quality of life (HRQoL) among patients with head and neck squamous cell carcinoma (HNSCC). Methods and Materials: Included were 241 patients with HNSCC treated with bilateral irradiation +/- chemotherapy. Since 2000, all patients treated with HNSCC were included in a program, which prospectively assessed acute and late morbidity according to the RTOG and HRQoL on a routine basis at regular intervals. Before October 2004, all patients were treated with 3D-CRT (N = 150). After clinical implementation in October 2004, 91 patients received IMRT. In this study, the differences regarding RTOG toxicity, xerostomia, and other items of HRQoL were analyzed. Results: The use of IMRT resulted in a significant reduction of the mean dose of the parotid glands (27 Gy vs. 43 Gy (p",

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Vergeer, MR, Doornaert, PAH, Rietveld, DHF , Leemans, CR , Slotman, BJ & Langendijk, JA 2009, 'Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of A Nonrandomized Prospective Study Using A Standardized Follow-Up Program', International journal of radiation oncology, biology, physics, vol. 74, no. 1, pp. 1-8. https://doi.org/10.1016/j.ijrobp.2008.07.059

Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of A Nonrandomized Prospective Study Using A Standardized Follow-Up Program. / Vergeer, M.R.; Doornaert, P.A.H.; Rietveld, D.H.F. et al.

In: International journal of radiation oncology, biology, physics, Vol. 74, No. 1, 2009, p. 1-8.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Doornaert, P.A.H.

AU - Rietveld, D.H.F.

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Vergeer MR, Doornaert PAH, Rietveld DHF , Leemans CR , Slotman BJ, Langendijk JA. Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of A Nonrandomized Prospective Study Using A Standardized Follow-Up Program. International journal of radiation oncology, biology, physics. 2009;74(1):1-8. https://doi.org/10.1016/j.ijrobp.2008.07.059