Interacties en dubbelmedicatie bij poliklinische patiënten met kanker

Translated title of the contribution: Drug interactions and duplicate prescriptions in outpatients receiving cancer treatment

Roelof W.F. Van Leeuwen, Eleonora L. Swart, Frits A. Boom, Martin G. Schuirenmaker, Jacqueline S. Hugtenburg

Research output: Contribution to journalArticleAcademicpeer-review


Objective: The pharmacotherapeutic treatment of patients with cancer is generally associated with multiple side-effects. Drug interactions can reinforce or intensify side-effects. We assessed the prevalence of drug interactions among ambulatory cancer patients being treated with cytotoxic drugs using a novel advanced screening method. Design and methods: The patients were asked to complete a questionnaire and an interview to obtain demographic and medication data. Drug interactions were identified by using electronic (Drug Interaction Facts software, version 4.0) and manual (e.g. PubMed) screening methods. Results: In this study 278 patients were enrolled and 348 potential drug interactions were identified. Of all patients 161 (58%; 95% confidence interval 52-64%) experienced at least one interaction. Of all drug interactions 34% was classified as major and 60% as moderate. In 40% of all drug interactions an anti-cancer agent and in 60% a supportive agent was involved. OTC drugs were involved in 11% of all drug interactions. Drug interactions with Cumarins, quinolones, anti-epileptics and hydrochlorothiazide were seen frequently. Interactions that potentially cause QT prolongation, gastroduodenal toxicity and CNS depression were also common. Duplicate prescriptions were not found. Conclusion: Potential drug interactions are common in (hemato)oncology. Screening for drug interactions should take place routinely before administering cytotoxic drugs.

Translated title of the contributionDrug interactions and duplicate prescriptions in outpatients receiving cancer treatment
Original languageDutch
Pages (from-to)99-103
Number of pages5
JournalPharmaceutisch Weekblad
Issue number24
Publication statusPublished - 18 Jun 2010

Cite this