Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: Mega-analytic findings from a large multi-site cohort

ENIGMA-MDD Consortium

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background. Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.MethodsWithin the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.ResultsCM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.ConclusionsSeverity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.
Original languageEnglish
JournalPsychological Medicine
DOIs
Publication statusPublished - 2019

Cite this

@article{6b7d55047def4802b60bb39cdda1f22b,
title = "Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: Mega-analytic findings from a large multi-site cohort",
abstract = "Background. Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.MethodsWithin the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.ResultsCM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.ConclusionsSeverity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.",
author = "{ENIGMA-MDD Consortium} and Leonardo Tozzi and Lisa Garczarek and Deborah Janowitz and Stein, {Dan J.} and Katharina Wittfeld and Henrik Dobrowolny and Jim Lagopoulos and Hatton, {Sean N.} and Hickie, {Ian B.} and Angela Carballedo and Brooks, {Samantha J.} and Daniella Vuletic and Anne Uhlmann and Veer, {Ilya M.} and Henrik Walter and Robin B{\"u}low and Henry V{\"o}lzke and Johanna Klinger-K{\"o}nig and Knut Schnell and Schoepf, {D. Ieter} and Dominik Grotegerd and Nils Opel and Udo Dannlowski and Harald Kugel and Elisabeth Schramm and Carsten Konrad and Tilo Kircher and J{\"u}ksel, {D. Ilara} and Igor Nenadic and Axel Krug and Tim Hahn and Olaf Steinstr{\"a}ter and Ronny Redlich and Dario Zaremba and Bartosz Zurowski and Fu, {Cynthia H. Y.} and Danai DIma and James Cole and Grabe, {Hans J.} and Connolly, {Colm G.} and Yang, {Tony T.} and Ho, {Tiffany C.} and Lewinn, {Kaja Z.} and Meng Li and Groenewold, {Nynke A.} and Salminen, {Lauren E.} and Martin Walter and Penninx, {Brenda W. J. H.} and Veltman, {D. Ick J.} and Lianne Schmaal",
year = "2019",
doi = "10.1017/S003329171900093X",
language = "English",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",

}

Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: Mega-analytic findings from a large multi-site cohort. / ENIGMA-MDD Consortium.

In: Psychological Medicine, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: Mega-analytic findings from a large multi-site cohort

AU - ENIGMA-MDD Consortium

AU - Tozzi, Leonardo

AU - Garczarek, Lisa

AU - Janowitz, Deborah

AU - Stein, Dan J.

AU - Wittfeld, Katharina

AU - Dobrowolny, Henrik

AU - Lagopoulos, Jim

AU - Hatton, Sean N.

AU - Hickie, Ian B.

AU - Carballedo, Angela

AU - Brooks, Samantha J.

AU - Vuletic, Daniella

AU - Uhlmann, Anne

AU - Veer, Ilya M.

AU - Walter, Henrik

AU - Bülow, Robin

AU - Völzke, Henry

AU - Klinger-König, Johanna

AU - Schnell, Knut

AU - Schoepf, D. Ieter

AU - Grotegerd, Dominik

AU - Opel, Nils

AU - Dannlowski, Udo

AU - Kugel, Harald

AU - Schramm, Elisabeth

AU - Konrad, Carsten

AU - Kircher, Tilo

AU - Jüksel, D. Ilara

AU - Nenadic, Igor

AU - Krug, Axel

AU - Hahn, Tim

AU - Steinsträter, Olaf

AU - Redlich, Ronny

AU - Zaremba, Dario

AU - Zurowski, Bartosz

AU - Fu, Cynthia H. Y.

AU - DIma, Danai

AU - Cole, James

AU - Grabe, Hans J.

AU - Connolly, Colm G.

AU - Yang, Tony T.

AU - Ho, Tiffany C.

AU - Lewinn, Kaja Z.

AU - Li, Meng

AU - Groenewold, Nynke A.

AU - Salminen, Lauren E.

AU - Walter, Martin

AU - Penninx, Brenda W. J. H.

AU - Veltman, D. Ick J.

AU - Schmaal, Lianne

PY - 2019

Y1 - 2019

N2 - Background. Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.MethodsWithin the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.ResultsCM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.ConclusionsSeverity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.

AB - Background. Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.MethodsWithin the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.ResultsCM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.ConclusionsSeverity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065738289&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31084657

U2 - 10.1017/S003329171900093X

DO - 10.1017/S003329171900093X

M3 - Article

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -