Intercellular adhesion molecule-1 in the heart

Hans W M Niessen; Paul A J Krijnen; Cees A Visser; Chris J L M Meijer; C Erik Hack

Intercellular adhesion molecule-1 in the heart

Hans W M Niessen, Paul A J Krijnen, Cees A Visser, Chris J L M Meijer, C Erik Hack

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

Original language	English
Pages (from-to)	573-85
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	973
Publication status	Published - Nov 2002

Cite this

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title = "Intercellular adhesion molecule-1 in the heart",

abstract = "Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.",

keywords = "Animals, Cell Adhesion, Cell Line, Gene Expression Regulation, Heart, Humans, Intercellular Adhesion Molecule-1, Myocardial Infarction, Myocardium, Transcription Factors, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "Niessen, {Hans W M} and Krijnen, {Paul A J} and Visser, {Cees A} and Meijer, {Chris J L M} and Hack, {C Erik}",

year = "2002",

month = nov,

language = "English",

volume = "973",

pages = "573--85",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Intercellular adhesion molecule-1 in the heart

AU - Niessen, Hans W M

AU - Krijnen, Paul A J

AU - Visser, Cees A

AU - Meijer, Chris J L M

AU - Hack, C Erik

PY - 2002/11

Y1 - 2002/11

N2 - Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

AB - Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

KW - Animals

KW - Cell Adhesion

KW - Cell Line

KW - Gene Expression Regulation

KW - Heart

KW - Humans

KW - Intercellular Adhesion Molecule-1

KW - Myocardial Infarction

KW - Myocardium

KW - Transcription Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

M3 - Review article

C2 - 12485931

VL - 973

SP - 573

EP - 585

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -