Abstract
Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.
| Original language | English |
|---|---|
| Pages (from-to) | 573-85 |
| Number of pages | 13 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 973 |
| Publication status | Published - Nov 2002 |
Cite this
Niessen, H. W. M., Krijnen, P. A. J., Visser, C. A., Meijer, C. J. L. M., & Hack, C. E. (2002). Intercellular adhesion molecule-1 in the heart. Annals of the New York Academy of Sciences, 973, 573-85.