Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis

Petra J G Zwijnenburg, Tom van der Poll, Sandrine Florquin, John J Roord, A Marceline van Furth

Research output: Contribution to journalArticleAcademicpeer-review


To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced.

Original languageEnglish
Pages (from-to)2276-9
Number of pages4
JournalInfection and Immunity
Issue number4
Publication statusPublished - Apr 2003

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