International multicentre review of perioperative management and outcome for catecholamine-producing tumours

H. Groeben, M. K. Walz, B. J. Nottebaum, P. F. Alesina, A. Greenwald, R. Schumann, M. W. Hollmann, L. Schwarte, M. Behrends, T. Rössel, C. Groeben, M. Schäfer, A. Lowery, N. Hirata, M. Yamakage, J. A. Miller, T. J. Cherry, A. Nelson, C. C. Solorzano, B. Gigliotti & 7 others T. S. Wang, J. K. G. Wietasch, P. Friederich, B. Sheppard, P. H. Graham, T. N. Weingarten, J. Sprung

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Surgery for catecholamine-producing tumours can be complicated by intraoperative and postoperative haemodynamic instability. Several perioperative management strategies have emerged but none has been evaluated in randomized trials. To assess this issue, contemporary perioperative management and outcome data from 21 centres were collected. Methods: Twenty-one centres contributed outcome data from patients who had surgery for phaeochromocytoma and paraganglioma between 2000 and 2017. The data included the number of patients with and without α-receptor blockade, surgical and anaesthetic techniques, complications and perioperative mortality. Results: Across all centres, data were reported on 1860 patients with phaeochromocytoma or paraganglioma, of whom 343 underwent surgery without α-receptor blockade. The majority of operations (78·9 per cent) were performed using minimally invasive techniques, including 16·1 per cent adrenal cortex-sparing procedures. The cardiovascular complication rate was 5·0 per cent overall: 5·9 per cent (90 of 1517) in patients with preoperative α-receptor blockade and 0·9 per cent (3 of 343) among patients without α-receptor blockade. The mortality rate was 0·5 per cent overall (9 of 1860): 0·5 per cent (8 of 517) in pretreated and 0·3 per cent (1 of 343) in non-pretreated patients. Conclusion: There is substantial variability in the perioperative management of catecholamine-producing tumours, yet the overall complication rate is low. Further studies are needed to better define the optimal management approach, and reappraisal of international perioperative guidelines appears desirable.
Original languageEnglish
Pages (from-to)e170-e178
JournalBritish Journal of Surgery
Volume107
Issue number2
DOIs
Publication statusPublished - 2020

Cite this

Groeben, H., Walz, M. K., Nottebaum, B. J., Alesina, P. F., Greenwald, A., Schumann, R., ... Sprung, J. (2020). International multicentre review of perioperative management and outcome for catecholamine-producing tumours. British Journal of Surgery, 107(2), e170-e178. https://doi.org/10.1002/bjs.11378
Groeben, H. ; Walz, M. K. ; Nottebaum, B. J. ; Alesina, P. F. ; Greenwald, A. ; Schumann, R. ; Hollmann, M. W. ; Schwarte, L. ; Behrends, M. ; Rössel, T. ; Groeben, C. ; Schäfer, M. ; Lowery, A. ; Hirata, N. ; Yamakage, M. ; Miller, J. A. ; Cherry, T. J. ; Nelson, A. ; Solorzano, C. C. ; Gigliotti, B. ; Wang, T. S. ; Wietasch, J. K. G. ; Friederich, P. ; Sheppard, B. ; Graham, P. H. ; Weingarten, T. N. ; Sprung, J. / International multicentre review of perioperative management and outcome for catecholamine-producing tumours. In: British Journal of Surgery. 2020 ; Vol. 107, No. 2. pp. e170-e178.
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title = "International multicentre review of perioperative management and outcome for catecholamine-producing tumours",
abstract = "Background: Surgery for catecholamine-producing tumours can be complicated by intraoperative and postoperative haemodynamic instability. Several perioperative management strategies have emerged but none has been evaluated in randomized trials. To assess this issue, contemporary perioperative management and outcome data from 21 centres were collected. Methods: Twenty-one centres contributed outcome data from patients who had surgery for phaeochromocytoma and paraganglioma between 2000 and 2017. The data included the number of patients with and without α-receptor blockade, surgical and anaesthetic techniques, complications and perioperative mortality. Results: Across all centres, data were reported on 1860 patients with phaeochromocytoma or paraganglioma, of whom 343 underwent surgery without α-receptor blockade. The majority of operations (78·9 per cent) were performed using minimally invasive techniques, including 16·1 per cent adrenal cortex-sparing procedures. The cardiovascular complication rate was 5·0 per cent overall: 5·9 per cent (90 of 1517) in patients with preoperative α-receptor blockade and 0·9 per cent (3 of 343) among patients without α-receptor blockade. The mortality rate was 0·5 per cent overall (9 of 1860): 0·5 per cent (8 of 517) in pretreated and 0·3 per cent (1 of 343) in non-pretreated patients. Conclusion: There is substantial variability in the perioperative management of catecholamine-producing tumours, yet the overall complication rate is low. Further studies are needed to better define the optimal management approach, and reappraisal of international perioperative guidelines appears desirable.",
author = "H. Groeben and Walz, {M. K.} and Nottebaum, {B. J.} and Alesina, {P. F.} and A. Greenwald and R. Schumann and Hollmann, {M. W.} and L. Schwarte and M. Behrends and T. R{\"o}ssel and C. Groeben and M. Sch{\"a}fer and A. Lowery and N. Hirata and M. Yamakage and Miller, {J. A.} and Cherry, {T. J.} and A. Nelson and Solorzano, {C. C.} and B. Gigliotti and Wang, {T. S.} and Wietasch, {J. K. G.} and P. Friederich and B. Sheppard and Graham, {P. H.} and Weingarten, {T. N.} and J. Sprung",
year = "2020",
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Groeben, H, Walz, MK, Nottebaum, BJ, Alesina, PF, Greenwald, A, Schumann, R, Hollmann, MW, Schwarte, L, Behrends, M, Rössel, T, Groeben, C, Schäfer, M, Lowery, A, Hirata, N, Yamakage, M, Miller, JA, Cherry, TJ, Nelson, A, Solorzano, CC, Gigliotti, B, Wang, TS, Wietasch, JKG, Friederich, P, Sheppard, B, Graham, PH, Weingarten, TN & Sprung, J 2020, 'International multicentre review of perioperative management and outcome for catecholamine-producing tumours' British Journal of Surgery, vol. 107, no. 2, pp. e170-e178. https://doi.org/10.1002/bjs.11378

International multicentre review of perioperative management and outcome for catecholamine-producing tumours. / Groeben, H.; Walz, M. K.; Nottebaum, B. J.; Alesina, P. F.; Greenwald, A.; Schumann, R.; Hollmann, M. W.; Schwarte, L.; Behrends, M.; Rössel, T.; Groeben, C.; Schäfer, M.; Lowery, A.; Hirata, N.; Yamakage, M.; Miller, J. A.; Cherry, T. J.; Nelson, A.; Solorzano, C. C.; Gigliotti, B.; Wang, T. S.; Wietasch, J. K. G.; Friederich, P.; Sheppard, B.; Graham, P. H.; Weingarten, T. N.; Sprung, J.

In: British Journal of Surgery, Vol. 107, No. 2, 2020, p. e170-e178.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - International multicentre review of perioperative management and outcome for catecholamine-producing tumours

AU - Groeben, H.

AU - Walz, M. K.

AU - Nottebaum, B. J.

AU - Alesina, P. F.

AU - Greenwald, A.

AU - Schumann, R.

AU - Hollmann, M. W.

AU - Schwarte, L.

AU - Behrends, M.

AU - Rössel, T.

AU - Groeben, C.

AU - Schäfer, M.

AU - Lowery, A.

AU - Hirata, N.

AU - Yamakage, M.

AU - Miller, J. A.

AU - Cherry, T. J.

AU - Nelson, A.

AU - Solorzano, C. C.

AU - Gigliotti, B.

AU - Wang, T. S.

AU - Wietasch, J. K. G.

AU - Friederich, P.

AU - Sheppard, B.

AU - Graham, P. H.

AU - Weingarten, T. N.

AU - Sprung, J.

PY - 2020

Y1 - 2020

N2 - Background: Surgery for catecholamine-producing tumours can be complicated by intraoperative and postoperative haemodynamic instability. Several perioperative management strategies have emerged but none has been evaluated in randomized trials. To assess this issue, contemporary perioperative management and outcome data from 21 centres were collected. Methods: Twenty-one centres contributed outcome data from patients who had surgery for phaeochromocytoma and paraganglioma between 2000 and 2017. The data included the number of patients with and without α-receptor blockade, surgical and anaesthetic techniques, complications and perioperative mortality. Results: Across all centres, data were reported on 1860 patients with phaeochromocytoma or paraganglioma, of whom 343 underwent surgery without α-receptor blockade. The majority of operations (78·9 per cent) were performed using minimally invasive techniques, including 16·1 per cent adrenal cortex-sparing procedures. The cardiovascular complication rate was 5·0 per cent overall: 5·9 per cent (90 of 1517) in patients with preoperative α-receptor blockade and 0·9 per cent (3 of 343) among patients without α-receptor blockade. The mortality rate was 0·5 per cent overall (9 of 1860): 0·5 per cent (8 of 517) in pretreated and 0·3 per cent (1 of 343) in non-pretreated patients. Conclusion: There is substantial variability in the perioperative management of catecholamine-producing tumours, yet the overall complication rate is low. Further studies are needed to better define the optimal management approach, and reappraisal of international perioperative guidelines appears desirable.

AB - Background: Surgery for catecholamine-producing tumours can be complicated by intraoperative and postoperative haemodynamic instability. Several perioperative management strategies have emerged but none has been evaluated in randomized trials. To assess this issue, contemporary perioperative management and outcome data from 21 centres were collected. Methods: Twenty-one centres contributed outcome data from patients who had surgery for phaeochromocytoma and paraganglioma between 2000 and 2017. The data included the number of patients with and without α-receptor blockade, surgical and anaesthetic techniques, complications and perioperative mortality. Results: Across all centres, data were reported on 1860 patients with phaeochromocytoma or paraganglioma, of whom 343 underwent surgery without α-receptor blockade. The majority of operations (78·9 per cent) were performed using minimally invasive techniques, including 16·1 per cent adrenal cortex-sparing procedures. The cardiovascular complication rate was 5·0 per cent overall: 5·9 per cent (90 of 1517) in patients with preoperative α-receptor blockade and 0·9 per cent (3 of 343) among patients without α-receptor blockade. The mortality rate was 0·5 per cent overall (9 of 1860): 0·5 per cent (8 of 517) in pretreated and 0·3 per cent (1 of 343) in non-pretreated patients. Conclusion: There is substantial variability in the perioperative management of catecholamine-producing tumours, yet the overall complication rate is low. Further studies are needed to better define the optimal management approach, and reappraisal of international perioperative guidelines appears desirable.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077322595&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31903598

U2 - 10.1002/bjs.11378

DO - 10.1002/bjs.11378

M3 - Article

VL - 107

SP - e170-e178

JO - British Journal of Surgery

JF - British Journal of Surgery

SN - 0007-1323

IS - 2

ER -