Interpretation of glucocorticoids in neonatal hair: A reflection of intrauterine glucocorticoid regulation?

Jonneke J. Hollanders, Bibian van der Voorn, Noera Kieviet, Koert M. Dolman, Yolanda B. de Rijke, Erica L.T. van den Akker, Joost Rotteveel, Adriaan Honig, Martijn J.J. Finken

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Glucocorticoids (GCs) measured in neonatal hair might reflect intrauterine as well as postpartum GC regulation. We aimed to identify factors associated with neonatal hair GC levels in early life, and their correlation with maternal hair GCs. Methods: In a single-center observational study, mother-infant pairs (n = 107) admitted for >72 h at the maternity ward of a general hospital were included. At birth and an outpatient visit (OPV, n = 72, 44 ± 11 days postpartum), maternal and neonatal hair was analyzed for cortisol and cortisone levels by LC-MS/MS. Data were analyzed regarding: (1) neonatal GC levels postpartum and at the OPV, (2) associations of neonatal GC levels with maternal GC levels and (3) with other perinatal factors. Results: (1) Neonatal GC levels were >5 times higher than maternal levels, with a decrease in ±50% between birth and the OPV for cortisol. (2) Maternal and neonatal cortisol, but not cortisone, levels were correlated both at postpartum and at the OPV. (3) Gestational age was associated with neonatal GC postpartum (log-transformed β (95% CI): cortisol 0.07 (0.04-0.10); cortisone 0.04 (0.01-0.06)) and at the OPV (cortisol 0.08 (0.04-0.12); cortisone 0.00 (-0.04 to 0.04)), while weaker associations were found between neonatal GCs and other perinatal and maternal factors. Conclusions: Neonatal hair GCs mainly reflect the third trimester increase in cortisol, which might be caused by the positive feedback loop, a placenta-driven phenomenon, represented by the positive association with GA. Between birth and 1.5 months postpartum, neonatal hair cortisol concentrations decrease sharply, but still appear to reflect both intra- and extrauterine periods.

Original languageEnglish
Pages (from-to)692-699
Number of pages8
JournalEndocrine Connections
Volume6
Issue number8
DOIs
Publication statusPublished - 1 Nov 2017

Cite this

@article{b07083881c784edba9e56fe43e76723e,
title = "Interpretation of glucocorticoids in neonatal hair: A reflection of intrauterine glucocorticoid regulation?",
abstract = "Background: Glucocorticoids (GCs) measured in neonatal hair might reflect intrauterine as well as postpartum GC regulation. We aimed to identify factors associated with neonatal hair GC levels in early life, and their correlation with maternal hair GCs. Methods: In a single-center observational study, mother-infant pairs (n = 107) admitted for >72 h at the maternity ward of a general hospital were included. At birth and an outpatient visit (OPV, n = 72, 44 ± 11 days postpartum), maternal and neonatal hair was analyzed for cortisol and cortisone levels by LC-MS/MS. Data were analyzed regarding: (1) neonatal GC levels postpartum and at the OPV, (2) associations of neonatal GC levels with maternal GC levels and (3) with other perinatal factors. Results: (1) Neonatal GC levels were >5 times higher than maternal levels, with a decrease in ±50{\%} between birth and the OPV for cortisol. (2) Maternal and neonatal cortisol, but not cortisone, levels were correlated both at postpartum and at the OPV. (3) Gestational age was associated with neonatal GC postpartum (log-transformed β (95{\%} CI): cortisol 0.07 (0.04-0.10); cortisone 0.04 (0.01-0.06)) and at the OPV (cortisol 0.08 (0.04-0.12); cortisone 0.00 (-0.04 to 0.04)), while weaker associations were found between neonatal GCs and other perinatal and maternal factors. Conclusions: Neonatal hair GCs mainly reflect the third trimester increase in cortisol, which might be caused by the positive feedback loop, a placenta-driven phenomenon, represented by the positive association with GA. Between birth and 1.5 months postpartum, neonatal hair cortisol concentrations decrease sharply, but still appear to reflect both intra- and extrauterine periods.",
keywords = "Cortisol, Cortisone, Hair glucocorticoids, HPA axis, Infant, Positive feedback loop",
author = "Hollanders, {Jonneke J.} and {van der Voorn}, Bibian and Noera Kieviet and Dolman, {Koert M.} and {de Rijke}, {Yolanda B.} and {van den Akker}, {Erica L.T.} and Joost Rotteveel and Adriaan Honig and Finken, {Martijn J.J.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1530/EC-17-0179",
language = "English",
volume = "6",
pages = "692--699",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BioScientifica Ltd.",
number = "8",

}

Interpretation of glucocorticoids in neonatal hair : A reflection of intrauterine glucocorticoid regulation? / Hollanders, Jonneke J.; van der Voorn, Bibian; Kieviet, Noera; Dolman, Koert M.; de Rijke, Yolanda B.; van den Akker, Erica L.T.; Rotteveel, Joost; Honig, Adriaan; Finken, Martijn J.J.

In: Endocrine Connections, Vol. 6, No. 8, 01.11.2017, p. 692-699.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Interpretation of glucocorticoids in neonatal hair

T2 - A reflection of intrauterine glucocorticoid regulation?

AU - Hollanders, Jonneke J.

AU - van der Voorn, Bibian

AU - Kieviet, Noera

AU - Dolman, Koert M.

AU - de Rijke, Yolanda B.

AU - van den Akker, Erica L.T.

AU - Rotteveel, Joost

AU - Honig, Adriaan

AU - Finken, Martijn J.J.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background: Glucocorticoids (GCs) measured in neonatal hair might reflect intrauterine as well as postpartum GC regulation. We aimed to identify factors associated with neonatal hair GC levels in early life, and their correlation with maternal hair GCs. Methods: In a single-center observational study, mother-infant pairs (n = 107) admitted for >72 h at the maternity ward of a general hospital were included. At birth and an outpatient visit (OPV, n = 72, 44 ± 11 days postpartum), maternal and neonatal hair was analyzed for cortisol and cortisone levels by LC-MS/MS. Data were analyzed regarding: (1) neonatal GC levels postpartum and at the OPV, (2) associations of neonatal GC levels with maternal GC levels and (3) with other perinatal factors. Results: (1) Neonatal GC levels were >5 times higher than maternal levels, with a decrease in ±50% between birth and the OPV for cortisol. (2) Maternal and neonatal cortisol, but not cortisone, levels were correlated both at postpartum and at the OPV. (3) Gestational age was associated with neonatal GC postpartum (log-transformed β (95% CI): cortisol 0.07 (0.04-0.10); cortisone 0.04 (0.01-0.06)) and at the OPV (cortisol 0.08 (0.04-0.12); cortisone 0.00 (-0.04 to 0.04)), while weaker associations were found between neonatal GCs and other perinatal and maternal factors. Conclusions: Neonatal hair GCs mainly reflect the third trimester increase in cortisol, which might be caused by the positive feedback loop, a placenta-driven phenomenon, represented by the positive association with GA. Between birth and 1.5 months postpartum, neonatal hair cortisol concentrations decrease sharply, but still appear to reflect both intra- and extrauterine periods.

AB - Background: Glucocorticoids (GCs) measured in neonatal hair might reflect intrauterine as well as postpartum GC regulation. We aimed to identify factors associated with neonatal hair GC levels in early life, and their correlation with maternal hair GCs. Methods: In a single-center observational study, mother-infant pairs (n = 107) admitted for >72 h at the maternity ward of a general hospital were included. At birth and an outpatient visit (OPV, n = 72, 44 ± 11 days postpartum), maternal and neonatal hair was analyzed for cortisol and cortisone levels by LC-MS/MS. Data were analyzed regarding: (1) neonatal GC levels postpartum and at the OPV, (2) associations of neonatal GC levels with maternal GC levels and (3) with other perinatal factors. Results: (1) Neonatal GC levels were >5 times higher than maternal levels, with a decrease in ±50% between birth and the OPV for cortisol. (2) Maternal and neonatal cortisol, but not cortisone, levels were correlated both at postpartum and at the OPV. (3) Gestational age was associated with neonatal GC postpartum (log-transformed β (95% CI): cortisol 0.07 (0.04-0.10); cortisone 0.04 (0.01-0.06)) and at the OPV (cortisol 0.08 (0.04-0.12); cortisone 0.00 (-0.04 to 0.04)), while weaker associations were found between neonatal GCs and other perinatal and maternal factors. Conclusions: Neonatal hair GCs mainly reflect the third trimester increase in cortisol, which might be caused by the positive feedback loop, a placenta-driven phenomenon, represented by the positive association with GA. Between birth and 1.5 months postpartum, neonatal hair cortisol concentrations decrease sharply, but still appear to reflect both intra- and extrauterine periods.

KW - Cortisol

KW - Cortisone

KW - Hair glucocorticoids

KW - HPA axis

KW - Infant

KW - Positive feedback loop

UR - http://www.scopus.com/inward/record.url?scp=85032729590&partnerID=8YFLogxK

U2 - 10.1530/EC-17-0179

DO - 10.1530/EC-17-0179

M3 - Article

VL - 6

SP - 692

EP - 699

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 8

ER -