This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects (benefits and harms) of interventions for preventing ankle ligament injuries and re-injuries. It is anticipated that the population will consist predominantly of individuals, from adolescence to middle age, who are participating in regular sports and other physical activities. Where possible, individuals undergoing rehabilitation for ankle sprains will be analysed separately. The specific objectives of this review are to assess differences in outcomes between: Any intervention aimed at the prevention of ankle ligament injuries versus no intervention; Different interventions aimed at the prevention of ankle ligament injuries.