TY - JOUR
T1 - Intestinal permeability in irritable bowel syndrome patients
T2 - Effects of NSAIDs
AU - Kerckhoffs, Angèle P.M.
AU - Akkermans, Louis M.A.
AU - De Smet, Martin B.M.
AU - Besselink, Marc G.H.
AU - Hietbrink, Falco
AU - Bartelink, Imke H.
AU - Busschers, Wim B.
AU - Samsom, Melvin
AU - Renooij, Willem
N1 - Funding Information:
Acknowledgments We acknowledge the staff of the Department of Pharmacy of the UMC Utrecht for production and supply of PEG and L/M test solutions. We thank M. van Loon, BSc, R. Voorbij, PhD, and coworkers of the Central Diagnostic Laboratory of the UMC Utrecht for the measurements of lactulose, mannitol, and creatinine. This work was funded in part by a Gastrostart grant from the Netherlands Society of Gastroenterology. APM Kerckhoffs was financially supported by Numico Research BV. LMA Akkermans received financial support from AstraZeneca R&D, Mölndal, Sweden. Supporting institutions were not involved in design, performance, or publication of this study.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/3
Y1 - 2010/3
N2 - Intestinal permeability and the effect of NSAIDs on permeability were investigated in 14 irritable bowel syndrome (IBS) patients and 15 healthy subjects. In the study, 24-h urinary recoveries of orally administered polyethylene glycols (PEGs 400, 1500, and 4000) were not significantly different in healthy subjects and IBS patients before or after NSAID ingestion. Lactulose mannitol ratios in healthy subjects and IBS patients were not significantly different. Only time-dependent monitoring of PEG excretion showed that NSAIDs enhanced intestinal permeability for PEG 4000 in healthy subjects (P = 0.050) and for PEGs 400, 1500, and 4000 in IBS patients (P = 0.012, P = 0.041, and P = 0.012, respectively). These results show that intestinal permeability in IBS patients is not different from that in healthy subjects; NSAIDs compromise intestinal permeability in IBS patients to a greater extent than in healthy subjects, which suggests that IBS is associated with an altered response of the intestinal barrier to noxious agents.
AB - Intestinal permeability and the effect of NSAIDs on permeability were investigated in 14 irritable bowel syndrome (IBS) patients and 15 healthy subjects. In the study, 24-h urinary recoveries of orally administered polyethylene glycols (PEGs 400, 1500, and 4000) were not significantly different in healthy subjects and IBS patients before or after NSAID ingestion. Lactulose mannitol ratios in healthy subjects and IBS patients were not significantly different. Only time-dependent monitoring of PEG excretion showed that NSAIDs enhanced intestinal permeability for PEG 4000 in healthy subjects (P = 0.050) and for PEGs 400, 1500, and 4000 in IBS patients (P = 0.012, P = 0.041, and P = 0.012, respectively). These results show that intestinal permeability in IBS patients is not different from that in healthy subjects; NSAIDs compromise intestinal permeability in IBS patients to a greater extent than in healthy subjects, which suggests that IBS is associated with an altered response of the intestinal barrier to noxious agents.
KW - IBS
KW - Intestinal permeability
KW - NSAIDs
KW - PEG
KW - Polyethylene glycol
UR - http://www.scopus.com/inward/record.url?scp=77949317353&partnerID=8YFLogxK
U2 - 10.1007/s10620-009-0765-9
DO - 10.1007/s10620-009-0765-9
M3 - Article
C2 - 19255843
AN - SCOPUS:77949317353
VL - 55
SP - 716
EP - 723
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 3
ER -