Is intracranial volume a suitable proxy for brain reserve? Rik Ossenkoppele

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Background: Brain reserve is a concept introduced to explain why Alzheimer's disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.

Original languageEnglish
Article number91
JournalAlzheimer's Research and Therapy
Volume10
Issue number1
DOIs
Publication statusPublished - 11 Sep 2018

Cite this

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title = "Is intracranial volume a suitable proxy for brain reserve? Rik Ossenkoppele",
abstract = "Background: Brain reserve is a concept introduced to explain why Alzheimer's disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.",
keywords = "Alzheimer's disease, Brain reserve, Dementia, Intracranial volume, MRI, Resilience",
author = "{Van Loenhoud}, {Anna Catharina} and Colin Groot and Vogel, {Jacob William} and {Van Der Flier}, {Wiesje Maria} and Rik Ossenkoppele",
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language = "English",
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journal = "Alzheimer's Research & Therapy",
issn = "1758-9193",
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Is intracranial volume a suitable proxy for brain reserve? Rik Ossenkoppele. / Van Loenhoud, Anna Catharina; Groot, Colin; Vogel, Jacob William; Van Der Flier, Wiesje Maria; Ossenkoppele, Rik.

In: Alzheimer's Research and Therapy, Vol. 10, No. 1, 91, 11.09.2018.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Is intracranial volume a suitable proxy for brain reserve? Rik Ossenkoppele

AU - Van Loenhoud, Anna Catharina

AU - Groot, Colin

AU - Vogel, Jacob William

AU - Van Der Flier, Wiesje Maria

AU - Ossenkoppele, Rik

PY - 2018/9/11

Y1 - 2018/9/11

N2 - Background: Brain reserve is a concept introduced to explain why Alzheimer's disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.

AB - Background: Brain reserve is a concept introduced to explain why Alzheimer's disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.

KW - Alzheimer's disease

KW - Brain reserve

KW - Dementia

KW - Intracranial volume

KW - MRI

KW - Resilience

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JO - Alzheimer's Research & Therapy

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