Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates?

S van der Weiden, E P de Jong, A B Te Pas, J M Middeldorp, A C T M Vossen, M Rijken, F J Walther, E Lopriore

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: congenital infections are associated with a wide variety of clinical symptoms, including small for gestational age (SGA).

AIMS: to determine the co-occurrence of SGA and congenital TORCH infections, as diagnosed by TORCH serologic tests and/or cytomegalovirus (CMV) urine culture.

STUDY DESIGN: we performed a retrospective study of all neonates admitted to our neonatal intensive care unit from January 2004 to February 2010 in whom SGA was diagnosed and TORCH serologic tests and/or CMV urine cultures were performed.

RESULTS: TORCH serologic tests (in neonatal or maternal serum) and/or a CMV urine culture were performed in 112 neonates with SGA. None of the neonates tested positive for Toxoplasma gondii, Rubella, and Herpes simplex virus. Positive CMV urine culture was detected in 2% (2/112) of neonates, but their CMV IgM titers were negative.

CONCLUSIONS: the co-occurrence of TORCH congenital infection in infants with SGA is rare. Routine TORCH screening in neonates with isolated SGA does not seem warranted and should be limited to CMV urine cultures.

Original languageEnglish
Pages (from-to)103-7
Number of pages5
JournalEarly Human Development
Volume87
Issue number2
DOIs
Publication statusPublished - Feb 2011

Cite this

van der Weiden, S., de Jong, E. P., Te Pas, A. B., Middeldorp, J. M., Vossen, A. C. T. M., Rijken, M., ... Lopriore, E. (2011). Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates? Early Human Development, 87(2), 103-7. https://doi.org/10.1016/j.earlhumdev.2010.11.005
van der Weiden, S ; de Jong, E P ; Te Pas, A B ; Middeldorp, J M ; Vossen, A C T M ; Rijken, M ; Walther, F J ; Lopriore, E. / Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates?. In: Early Human Development. 2011 ; Vol. 87, No. 2. pp. 103-7.
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abstract = "BACKGROUND: congenital infections are associated with a wide variety of clinical symptoms, including small for gestational age (SGA).AIMS: to determine the co-occurrence of SGA and congenital TORCH infections, as diagnosed by TORCH serologic tests and/or cytomegalovirus (CMV) urine culture.STUDY DESIGN: we performed a retrospective study of all neonates admitted to our neonatal intensive care unit from January 2004 to February 2010 in whom SGA was diagnosed and TORCH serologic tests and/or CMV urine cultures were performed.RESULTS: TORCH serologic tests (in neonatal or maternal serum) and/or a CMV urine culture were performed in 112 neonates with SGA. None of the neonates tested positive for Toxoplasma gondii, Rubella, and Herpes simplex virus. Positive CMV urine culture was detected in 2{\%} (2/112) of neonates, but their CMV IgM titers were negative.CONCLUSIONS: the co-occurrence of TORCH congenital infection in infants with SGA is rare. Routine TORCH screening in neonates with isolated SGA does not seem warranted and should be limited to CMV urine cultures.",
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van der Weiden, S, de Jong, EP, Te Pas, AB, Middeldorp, JM, Vossen, ACTM, Rijken, M, Walther, FJ & Lopriore, E 2011, 'Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates?' Early Human Development, vol. 87, no. 2, pp. 103-7. https://doi.org/10.1016/j.earlhumdev.2010.11.005

Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates? / van der Weiden, S; de Jong, E P; Te Pas, A B; Middeldorp, J M; Vossen, A C T M; Rijken, M; Walther, F J; Lopriore, E.

In: Early Human Development, Vol. 87, No. 2, 02.2011, p. 103-7.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates?

AU - van der Weiden, S

AU - de Jong, E P

AU - Te Pas, A B

AU - Middeldorp, J M

AU - Vossen, A C T M

AU - Rijken, M

AU - Walther, F J

AU - Lopriore, E

N1 - 2010 Elsevier Ltd. All rights reserved.

PY - 2011/2

Y1 - 2011/2

N2 - BACKGROUND: congenital infections are associated with a wide variety of clinical symptoms, including small for gestational age (SGA).AIMS: to determine the co-occurrence of SGA and congenital TORCH infections, as diagnosed by TORCH serologic tests and/or cytomegalovirus (CMV) urine culture.STUDY DESIGN: we performed a retrospective study of all neonates admitted to our neonatal intensive care unit from January 2004 to February 2010 in whom SGA was diagnosed and TORCH serologic tests and/or CMV urine cultures were performed.RESULTS: TORCH serologic tests (in neonatal or maternal serum) and/or a CMV urine culture were performed in 112 neonates with SGA. None of the neonates tested positive for Toxoplasma gondii, Rubella, and Herpes simplex virus. Positive CMV urine culture was detected in 2% (2/112) of neonates, but their CMV IgM titers were negative.CONCLUSIONS: the co-occurrence of TORCH congenital infection in infants with SGA is rare. Routine TORCH screening in neonates with isolated SGA does not seem warranted and should be limited to CMV urine cultures.

AB - BACKGROUND: congenital infections are associated with a wide variety of clinical symptoms, including small for gestational age (SGA).AIMS: to determine the co-occurrence of SGA and congenital TORCH infections, as diagnosed by TORCH serologic tests and/or cytomegalovirus (CMV) urine culture.STUDY DESIGN: we performed a retrospective study of all neonates admitted to our neonatal intensive care unit from January 2004 to February 2010 in whom SGA was diagnosed and TORCH serologic tests and/or CMV urine cultures were performed.RESULTS: TORCH serologic tests (in neonatal or maternal serum) and/or a CMV urine culture were performed in 112 neonates with SGA. None of the neonates tested positive for Toxoplasma gondii, Rubella, and Herpes simplex virus. Positive CMV urine culture was detected in 2% (2/112) of neonates, but their CMV IgM titers were negative.CONCLUSIONS: the co-occurrence of TORCH congenital infection in infants with SGA is rare. Routine TORCH screening in neonates with isolated SGA does not seem warranted and should be limited to CMV urine cultures.

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KW - Cytomegalovirus

KW - Cytomegalovirus Infections

KW - Diagnostic Tests, Routine

KW - Herpes Simplex

KW - Humans

KW - Infant, Newborn

KW - Infant, Newborn, Diseases

KW - Infant, Small for Gestational Age

KW - Medical Futility

KW - Retrospective Studies

KW - Rubella

KW - Serologic Tests

KW - Toxoplasma

KW - Toxoplasmosis, Congenital

KW - Urinalysis

KW - Virology

KW - Evaluation Studies

KW - Journal Article

U2 - 10.1016/j.earlhumdev.2010.11.005

DO - 10.1016/j.earlhumdev.2010.11.005

M3 - Article

VL - 87

SP - 103

EP - 107

JO - Early Human Development

JF - Early Human Development

SN - 0378-3782

IS - 2

ER -