Ischemic lesion volume correlates with long-term functional outcome and quality of life of middle cerebral artery stroke survivors

S. K. Schiemanck, M. W.M. Post, G. Kwakkel, Th D. Witkamp, L. J. Kappelle, A. J.H. Prevo

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Abstract

Purpose: Previous studies investigating relationships between stroke lesion volume and outcome were restricted to short follow-up periods (3-6 months) and outcome measures of stroke severity and activities only, whereas functional improvement has been found to extend far beyond six months. Therefore, this study investigated relationships between infarct volume and a broad range of outcomes of stroke survivors at a long follow-up period. Methods: Correlations between lesion volumes (determined by conventional MRI scans in the second week post-stroke) and outcomes after one year of 75 first-ever ischemic stroke survivors were investigated. Results: Moderate Spearman Rank correlation coefficients were found between lesion volume and motor impairment (Motricity Index (MI): -0.43, p < 0.01; Fugl Meyer Motor Assessment Scale (FM): -0.43; p < 0.01). Correlation coefficients with activities of daily living were moderate but low associated with Barthel Index (rs = 0.30; p < 0.01), modified Rankin Scale (rs = 0.39; p < 0.01) and Frenchay Activities Index (rs = -0.35; p < 0.01). Lesion volume had a significant but low association (rs = 0.27; p = 0.02) with patient's health status measured with Sickness Impact Profile 68 (SIP68)) and a moderate correlation with well-being assessed with Life Satisfaction Questionnaire (LSQ; rs = -0.45; p < 0.01). Found correlation coefficients were slightly stronger after correction for mixed (cortical/subcortical) and purely subcortical lesion location. Conclusions: It can be concluded that infarct volume moderately correlates with long-term motor impairment, functional outcome and quality of life of patients surviving stroke.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalRestorative Neurology and Neuroscience
Volume23
Issue number3-4
Publication statusPublished - 23 Aug 2005

Cite this

Schiemanck, S. K. ; Post, M. W.M. ; Kwakkel, G. ; Witkamp, Th D. ; Kappelle, L. J. ; Prevo, A. J.H. / Ischemic lesion volume correlates with long-term functional outcome and quality of life of middle cerebral artery stroke survivors. In: Restorative Neurology and Neuroscience. 2005 ; Vol. 23, No. 3-4. pp. 257-263.
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abstract = "Purpose: Previous studies investigating relationships between stroke lesion volume and outcome were restricted to short follow-up periods (3-6 months) and outcome measures of stroke severity and activities only, whereas functional improvement has been found to extend far beyond six months. Therefore, this study investigated relationships between infarct volume and a broad range of outcomes of stroke survivors at a long follow-up period. Methods: Correlations between lesion volumes (determined by conventional MRI scans in the second week post-stroke) and outcomes after one year of 75 first-ever ischemic stroke survivors were investigated. Results: Moderate Spearman Rank correlation coefficients were found between lesion volume and motor impairment (Motricity Index (MI): -0.43, p < 0.01; Fugl Meyer Motor Assessment Scale (FM): -0.43; p < 0.01). Correlation coefficients with activities of daily living were moderate but low associated with Barthel Index (rs = 0.30; p < 0.01), modified Rankin Scale (rs = 0.39; p < 0.01) and Frenchay Activities Index (rs = -0.35; p < 0.01). Lesion volume had a significant but low association (rs = 0.27; p = 0.02) with patient's health status measured with Sickness Impact Profile 68 (SIP68)) and a moderate correlation with well-being assessed with Life Satisfaction Questionnaire (LSQ; rs = -0.45; p < 0.01). Found correlation coefficients were slightly stronger after correction for mixed (cortical/subcortical) and purely subcortical lesion location. Conclusions: It can be concluded that infarct volume moderately correlates with long-term motor impairment, functional outcome and quality of life of patients surviving stroke.",
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Ischemic lesion volume correlates with long-term functional outcome and quality of life of middle cerebral artery stroke survivors. / Schiemanck, S. K.; Post, M. W.M.; Kwakkel, G.; Witkamp, Th D.; Kappelle, L. J.; Prevo, A. J.H.

In: Restorative Neurology and Neuroscience, Vol. 23, No. 3-4, 23.08.2005, p. 257-263.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Ischemic lesion volume correlates with long-term functional outcome and quality of life of middle cerebral artery stroke survivors

AU - Schiemanck, S. K.

AU - Post, M. W.M.

AU - Kwakkel, G.

AU - Witkamp, Th D.

AU - Kappelle, L. J.

AU - Prevo, A. J.H.

PY - 2005/8/23

Y1 - 2005/8/23

N2 - Purpose: Previous studies investigating relationships between stroke lesion volume and outcome were restricted to short follow-up periods (3-6 months) and outcome measures of stroke severity and activities only, whereas functional improvement has been found to extend far beyond six months. Therefore, this study investigated relationships between infarct volume and a broad range of outcomes of stroke survivors at a long follow-up period. Methods: Correlations between lesion volumes (determined by conventional MRI scans in the second week post-stroke) and outcomes after one year of 75 first-ever ischemic stroke survivors were investigated. Results: Moderate Spearman Rank correlation coefficients were found between lesion volume and motor impairment (Motricity Index (MI): -0.43, p < 0.01; Fugl Meyer Motor Assessment Scale (FM): -0.43; p < 0.01). Correlation coefficients with activities of daily living were moderate but low associated with Barthel Index (rs = 0.30; p < 0.01), modified Rankin Scale (rs = 0.39; p < 0.01) and Frenchay Activities Index (rs = -0.35; p < 0.01). Lesion volume had a significant but low association (rs = 0.27; p = 0.02) with patient's health status measured with Sickness Impact Profile 68 (SIP68)) and a moderate correlation with well-being assessed with Life Satisfaction Questionnaire (LSQ; rs = -0.45; p < 0.01). Found correlation coefficients were slightly stronger after correction for mixed (cortical/subcortical) and purely subcortical lesion location. Conclusions: It can be concluded that infarct volume moderately correlates with long-term motor impairment, functional outcome and quality of life of patients surviving stroke.

AB - Purpose: Previous studies investigating relationships between stroke lesion volume and outcome were restricted to short follow-up periods (3-6 months) and outcome measures of stroke severity and activities only, whereas functional improvement has been found to extend far beyond six months. Therefore, this study investigated relationships between infarct volume and a broad range of outcomes of stroke survivors at a long follow-up period. Methods: Correlations between lesion volumes (determined by conventional MRI scans in the second week post-stroke) and outcomes after one year of 75 first-ever ischemic stroke survivors were investigated. Results: Moderate Spearman Rank correlation coefficients were found between lesion volume and motor impairment (Motricity Index (MI): -0.43, p < 0.01; Fugl Meyer Motor Assessment Scale (FM): -0.43; p < 0.01). Correlation coefficients with activities of daily living were moderate but low associated with Barthel Index (rs = 0.30; p < 0.01), modified Rankin Scale (rs = 0.39; p < 0.01) and Frenchay Activities Index (rs = -0.35; p < 0.01). Lesion volume had a significant but low association (rs = 0.27; p = 0.02) with patient's health status measured with Sickness Impact Profile 68 (SIP68)) and a moderate correlation with well-being assessed with Life Satisfaction Questionnaire (LSQ; rs = -0.45; p < 0.01). Found correlation coefficients were slightly stronger after correction for mixed (cortical/subcortical) and purely subcortical lesion location. Conclusions: It can be concluded that infarct volume moderately correlates with long-term motor impairment, functional outcome and quality of life of patients surviving stroke.

KW - Infarction

KW - Lesion volume

KW - Magnetic resonance imaging

KW - Middle cerebral artery

KW - Outcome

KW - Quality of life

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M3 - Article

VL - 23

SP - 257

EP - 263

JO - Restorative Neurology and Neuroscience

JF - Restorative Neurology and Neuroscience

SN - 0922-6028

IS - 3-4

ER -