Isotropic 3D fast FLAIR imaging of the brain in multiple sclerosis patients: Initial experience

I. L. Tan, P. J.W. Pouwels, R. A. van Schijndel, H. J. Adèr, R. A. Manoliu, F. Barkhof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The application of image registration and subtraction to detect change in multiple sclerosis (MS) disease burden on serial MR scans benefits from the use of isotropic voxels. An optimised 3D fast fluid-attenuated inversion recovery (FLAIR) sequence with 1.2- and 1.8-mm cubic voxels was compared with a 2D T2 SE sequence using standard 3-mm slices. Three-dimensional fast FLAIR and T2 SE series were obtained in 20 MS patients and 15 controls. Whole brain acquisition times for the 1.2- and 1.8-mm FLAIR were 21 and 10.5 min, respectively, for the interleaved T2 SE 16 min. Brain lesions were marked in consensus by two radiologists and the CNR was calculated in ten lesions. The mean number of lesions detected with the 1.2-mm FLAIR sequence was 115±76, compared with 85±59 for the T2 SE series (p<0.001). The 1.8-mm FLAIR detected only 73±46 lesions. The CNR of the 1.2-mm FLAIR was significantly better than the T2 SE (p<0.01), but not as good as the 1.8-mm FLAIR. In conclusion, isotropic 3D fast FLAIR using 1.2-mm cubic voxels is superior to the 2D T2 SE in the detection of brain lesions in MS patients. The isotropic 1.8-mm FLAIR is faster and has better contrast characteristics but lacks sensitivity.

Original languageEnglish
Pages (from-to)559-567
Number of pages9
JournalEuropean Radiology
Volume12
Issue number3
DOIs
Publication statusPublished - 1 Mar 2002

Cite this

Tan, I. L. ; Pouwels, P. J.W. ; van Schijndel, R. A. ; Adèr, H. J. ; Manoliu, R. A. ; Barkhof, F. / Isotropic 3D fast FLAIR imaging of the brain in multiple sclerosis patients : Initial experience. In: European Radiology. 2002 ; Vol. 12, No. 3. pp. 559-567.
@article{f8e325f1673a45e797f2063dcc091c0d,
title = "Isotropic 3D fast FLAIR imaging of the brain in multiple sclerosis patients: Initial experience",
abstract = "The application of image registration and subtraction to detect change in multiple sclerosis (MS) disease burden on serial MR scans benefits from the use of isotropic voxels. An optimised 3D fast fluid-attenuated inversion recovery (FLAIR) sequence with 1.2- and 1.8-mm cubic voxels was compared with a 2D T2 SE sequence using standard 3-mm slices. Three-dimensional fast FLAIR and T2 SE series were obtained in 20 MS patients and 15 controls. Whole brain acquisition times for the 1.2- and 1.8-mm FLAIR were 21 and 10.5 min, respectively, for the interleaved T2 SE 16 min. Brain lesions were marked in consensus by two radiologists and the CNR was calculated in ten lesions. The mean number of lesions detected with the 1.2-mm FLAIR sequence was 115±76, compared with 85±59 for the T2 SE series (p<0.001). The 1.8-mm FLAIR detected only 73±46 lesions. The CNR of the 1.2-mm FLAIR was significantly better than the T2 SE (p<0.01), but not as good as the 1.8-mm FLAIR. In conclusion, isotropic 3D fast FLAIR using 1.2-mm cubic voxels is superior to the 2D T2 SE in the detection of brain lesions in MS patients. The isotropic 1.8-mm FLAIR is faster and has better contrast characteristics but lacks sensitivity.",
keywords = "3D, FLAIR, Image registration, MR imaging, Multiple sclerosis",
author = "Tan, {I. L.} and Pouwels, {P. J.W.} and {van Schijndel}, {R. A.} and Ad{\`e}r, {H. J.} and Manoliu, {R. A.} and F. Barkhof",
year = "2002",
month = "3",
day = "1",
doi = "10.1007/s00330-001-1170-8",
language = "English",
volume = "12",
pages = "559--567",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "3",

}

Isotropic 3D fast FLAIR imaging of the brain in multiple sclerosis patients : Initial experience. / Tan, I. L.; Pouwels, P. J.W.; van Schijndel, R. A.; Adèr, H. J.; Manoliu, R. A.; Barkhof, F.

In: European Radiology, Vol. 12, No. 3, 01.03.2002, p. 559-567.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Isotropic 3D fast FLAIR imaging of the brain in multiple sclerosis patients

T2 - Initial experience

AU - Tan, I. L.

AU - Pouwels, P. J.W.

AU - van Schijndel, R. A.

AU - Adèr, H. J.

AU - Manoliu, R. A.

AU - Barkhof, F.

PY - 2002/3/1

Y1 - 2002/3/1

N2 - The application of image registration and subtraction to detect change in multiple sclerosis (MS) disease burden on serial MR scans benefits from the use of isotropic voxels. An optimised 3D fast fluid-attenuated inversion recovery (FLAIR) sequence with 1.2- and 1.8-mm cubic voxels was compared with a 2D T2 SE sequence using standard 3-mm slices. Three-dimensional fast FLAIR and T2 SE series were obtained in 20 MS patients and 15 controls. Whole brain acquisition times for the 1.2- and 1.8-mm FLAIR were 21 and 10.5 min, respectively, for the interleaved T2 SE 16 min. Brain lesions were marked in consensus by two radiologists and the CNR was calculated in ten lesions. The mean number of lesions detected with the 1.2-mm FLAIR sequence was 115±76, compared with 85±59 for the T2 SE series (p<0.001). The 1.8-mm FLAIR detected only 73±46 lesions. The CNR of the 1.2-mm FLAIR was significantly better than the T2 SE (p<0.01), but not as good as the 1.8-mm FLAIR. In conclusion, isotropic 3D fast FLAIR using 1.2-mm cubic voxels is superior to the 2D T2 SE in the detection of brain lesions in MS patients. The isotropic 1.8-mm FLAIR is faster and has better contrast characteristics but lacks sensitivity.

AB - The application of image registration and subtraction to detect change in multiple sclerosis (MS) disease burden on serial MR scans benefits from the use of isotropic voxels. An optimised 3D fast fluid-attenuated inversion recovery (FLAIR) sequence with 1.2- and 1.8-mm cubic voxels was compared with a 2D T2 SE sequence using standard 3-mm slices. Three-dimensional fast FLAIR and T2 SE series were obtained in 20 MS patients and 15 controls. Whole brain acquisition times for the 1.2- and 1.8-mm FLAIR were 21 and 10.5 min, respectively, for the interleaved T2 SE 16 min. Brain lesions were marked in consensus by two radiologists and the CNR was calculated in ten lesions. The mean number of lesions detected with the 1.2-mm FLAIR sequence was 115±76, compared with 85±59 for the T2 SE series (p<0.001). The 1.8-mm FLAIR detected only 73±46 lesions. The CNR of the 1.2-mm FLAIR was significantly better than the T2 SE (p<0.01), but not as good as the 1.8-mm FLAIR. In conclusion, isotropic 3D fast FLAIR using 1.2-mm cubic voxels is superior to the 2D T2 SE in the detection of brain lesions in MS patients. The isotropic 1.8-mm FLAIR is faster and has better contrast characteristics but lacks sensitivity.

KW - 3D

KW - FLAIR

KW - Image registration

KW - MR imaging

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0036517934&partnerID=8YFLogxK

U2 - 10.1007/s00330-001-1170-8

DO - 10.1007/s00330-001-1170-8

M3 - Article

VL - 12

SP - 559

EP - 567

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 3

ER -