Keep your macrophages fit for healthy aging

Jan Van den Bossche*, Pieter J.M. Leenen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

As age is the greatest risk factor for the development of most prevalent chronic diseases, there is an enormous interest in understanding the process of aging, with the hope of delaying or preventing age-related comorbidities. Along these lines, a recent study by Minhas et al. (2021) describes how aged macrophages downregulate glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), inducing an energy-deficient state that compromises macrophage function and supports maladaptive inflammation that together cause brain dysfunction.

Original languageEnglish
Pages (from-to)468-470
Number of pages3
JournalCell Metabolism
Volume33
Issue number3
DOIs
Publication statusPublished - 2 Mar 2021

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