Kinetics and 28-day test-retest repeatability and reproducibility of [11C]UCB-J PET brain imaging

Hayel Tuncel, Ronald Boellaard, Emma M Coomans, Erik Fj de Vries, Andor Wjm Glaudemans, Paula Kopschina Feltes, David V García, Sander Cj Verfaillie, Emma E Wolters, Steven P Sweeney, J Michael Ryan, Magnus Ivarsson, Berkley A Lynch, Patrick Schober, Philip Scheltens, Robert C Schuit, Albert D Windhorst, Peter P De Deyn, Bart Nm van Berckel, Sandeep Sv Golla

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

[11C]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A). The main objective of this study was to determine the 28-day test-retest repeatability (TRT) of quantitative [11C]UCB-J brain positron emission tomography (PET) imaging in Alzheimer's disease (AD) patients and healthy controls (HCs). Nine HCs and eight AD patients underwent two 60 min dynamic [11C]UCB-J PET scans with arterial sampling with an interval of 28 days. The optimal tracer kinetic model was assessed using the Akaike criteria (AIC). Micro-/macro-parameters such as tracer delivery (K1) and volume of distribution (VT) were estimated using the optimal model. Data were also analysed for simplified reference tissue model (SRTM) with centrum semi-ovale (white matter) as reference region. Based on AIC, both 1T2k_VB and 2T4k_VB described the [11C]UCB-J kinetics equally well. Analysis showed that whole-brain grey matter TRT for VT, DVR and SRTM BPND were -2.2% ± 8.5, 0.4% ± 12.0 and -8.0% ± 10.2, averaged over all subjects. [11C]UCB-J kinetics can be well described by a 1T2k_VB model, and a 60 min scan duration was sufficient to obtain reliable estimates for both plasma input and reference tissue models. TRT for VT, DVR and BPND was <15% (1SD) averaged over all subjects and indicates adequate quantitative repeatability of [11C]UCB-J PET.

Original languageEnglish
Pages (from-to)1338-1350
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume41
Issue number6
Early online date2020
DOIs
Publication statusPublished - Jun 2021

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