KLIFS: an overhaul after the first 5 years of supporting kinase research

Georgi K Kanev, Chris de Graaf, Bart A Westerman, Iwan J P de Esch, Albert J Kooistra

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family, a wealth of data has been accumulated that keeps on growing. KLIFS-Kinase-Ligand Interaction Fingerprints and Structures-is a structural database focusing on how kinase inhibitors interact with their targets. The aim of KLIFS is to support (structure-based) kinase research through the systematic collection, annotation, and processing of kinase structures. Now, 5 years after releasing the initial KLIFS website, the database has undergone a complete overhaul with a new website, new logo, and new functionalities. In this article, we start by looking back at how KLIFS has been used by the research community, followed by a description of the renewed KLIFS, and conclude with showcasing the functionalities of KLIFS. Major changes include the integration of approved drugs and inhibitors in clinical trials, extension of the coverage to atypical kinases, and a RESTful API for programmatic access. KLIFS is available at the new domain https://klifs.net.

Original languageEnglish
Pages (from-to)D562-D569
JournalNucleic Acids Research
Volume49
Issue numberD1
DOIs
Publication statusPublished - 8 Jan 2021

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