Laparoscopic antireflux surgery increases health-related quality of life in children with GERD

Femke A Mauritz, Rebecca K Stellato, L W Ernst van Heurn, Peter D Siersema, Cornelius E J Sloots, Roderick H J Houwen, David C van der Zee, Maud Y A van Herwaarden-Lindeboom

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

INTRODUCTION: Improving health-related quality of life (HRQoL) is increasingly recognized as an essential part of patient care outcome. Little is known about the effect of laparoscopic antireflux surgery (LARS) on the HRQoL in the pediatric patients. The aims of this study were to evaluate the effect of LARS on HRQoL in children with gastroesophageal reflux disease (GERD) and to identify predictors that influence HRQoL outcome after LARS.

METHODS: Between 2011 and 2013, 25 patients with therapy-resistant GERD [median age 6 (2-18) years] were included prospectively. Caregivers and children with normal neurodevelopment (>4 years) were asked to fill out the validated PedsQL 4.0 Generic Core Scales before and 3-4 months after LARS.

RESULTS: The PedsQL was completed by all caregivers (n = 25) and 12 children. HRQoL total score improved significantly after LARS, both from a parental (p = 0.009) and child's perspective (p = 0.018). The psychosocial health summary and physical health summary scores also improved significantly after LARS. HRQoL before and after LARS was significantly lower in children with impaired neurodevelopment (p < 0.001). However, neurodevelopment did not influence the effect of LARS on HRQoL. The only significant predictor for improvement in HRQoL after LARS was age at the time of operation (p = 0.001).

CONCLUSIONS: HRQoL significantly improves after LARS. Although children with impaired neurodevelopment had lower overall HRQoL, neurodevelopment by itself does not predict inferior improvement in HRQoL after LARS. Older children have a more favorable HRQoL outcome after LARS compared to younger children. This may suggest caution when considering LARS in younger GERD patients.

Original languageEnglish
Pages (from-to)3122-3129
Number of pages8
JournalSurgical Endoscopy
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 2017
Externally publishedYes

Cite this

Mauritz, F. A., Stellato, R. K., van Heurn, L. W. E., Siersema, P. D., Sloots, C. E. J., Houwen, R. H. J., ... van Herwaarden-Lindeboom, M. Y. A. (2017). Laparoscopic antireflux surgery increases health-related quality of life in children with GERD. Surgical Endoscopy, 31(8), 3122-3129. https://doi.org/10.1007/s00464-016-5336-5
Mauritz, Femke A ; Stellato, Rebecca K ; van Heurn, L W Ernst ; Siersema, Peter D ; Sloots, Cornelius E J ; Houwen, Roderick H J ; van der Zee, David C ; van Herwaarden-Lindeboom, Maud Y A. / Laparoscopic antireflux surgery increases health-related quality of life in children with GERD. In: Surgical Endoscopy. 2017 ; Vol. 31, No. 8. pp. 3122-3129.
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title = "Laparoscopic antireflux surgery increases health-related quality of life in children with GERD",
abstract = "INTRODUCTION: Improving health-related quality of life (HRQoL) is increasingly recognized as an essential part of patient care outcome. Little is known about the effect of laparoscopic antireflux surgery (LARS) on the HRQoL in the pediatric patients. The aims of this study were to evaluate the effect of LARS on HRQoL in children with gastroesophageal reflux disease (GERD) and to identify predictors that influence HRQoL outcome after LARS.METHODS: Between 2011 and 2013, 25 patients with therapy-resistant GERD [median age 6 (2-18) years] were included prospectively. Caregivers and children with normal neurodevelopment (>4 years) were asked to fill out the validated PedsQL 4.0 Generic Core Scales before and 3-4 months after LARS.RESULTS: The PedsQL was completed by all caregivers (n = 25) and 12 children. HRQoL total score improved significantly after LARS, both from a parental (p = 0.009) and child's perspective (p = 0.018). The psychosocial health summary and physical health summary scores also improved significantly after LARS. HRQoL before and after LARS was significantly lower in children with impaired neurodevelopment (p < 0.001). However, neurodevelopment did not influence the effect of LARS on HRQoL. The only significant predictor for improvement in HRQoL after LARS was age at the time of operation (p = 0.001).CONCLUSIONS: HRQoL significantly improves after LARS. Although children with impaired neurodevelopment had lower overall HRQoL, neurodevelopment by itself does not predict inferior improvement in HRQoL after LARS. Older children have a more favorable HRQoL outcome after LARS compared to younger children. This may suggest caution when considering LARS in younger GERD patients.",
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Mauritz, FA, Stellato, RK, van Heurn, LWE, Siersema, PD, Sloots, CEJ, Houwen, RHJ, van der Zee, DC & van Herwaarden-Lindeboom, MYA 2017, 'Laparoscopic antireflux surgery increases health-related quality of life in children with GERD' Surgical Endoscopy, vol. 31, no. 8, pp. 3122-3129. https://doi.org/10.1007/s00464-016-5336-5

Laparoscopic antireflux surgery increases health-related quality of life in children with GERD. / Mauritz, Femke A; Stellato, Rebecca K; van Heurn, L W Ernst; Siersema, Peter D; Sloots, Cornelius E J; Houwen, Roderick H J; van der Zee, David C; van Herwaarden-Lindeboom, Maud Y A.

In: Surgical Endoscopy, Vol. 31, No. 8, 08.2017, p. 3122-3129.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Laparoscopic antireflux surgery increases health-related quality of life in children with GERD

AU - Mauritz, Femke A

AU - Stellato, Rebecca K

AU - van Heurn, L W Ernst

AU - Siersema, Peter D

AU - Sloots, Cornelius E J

AU - Houwen, Roderick H J

AU - van der Zee, David C

AU - van Herwaarden-Lindeboom, Maud Y A

PY - 2017/8

Y1 - 2017/8

N2 - INTRODUCTION: Improving health-related quality of life (HRQoL) is increasingly recognized as an essential part of patient care outcome. Little is known about the effect of laparoscopic antireflux surgery (LARS) on the HRQoL in the pediatric patients. The aims of this study were to evaluate the effect of LARS on HRQoL in children with gastroesophageal reflux disease (GERD) and to identify predictors that influence HRQoL outcome after LARS.METHODS: Between 2011 and 2013, 25 patients with therapy-resistant GERD [median age 6 (2-18) years] were included prospectively. Caregivers and children with normal neurodevelopment (>4 years) were asked to fill out the validated PedsQL 4.0 Generic Core Scales before and 3-4 months after LARS.RESULTS: The PedsQL was completed by all caregivers (n = 25) and 12 children. HRQoL total score improved significantly after LARS, both from a parental (p = 0.009) and child's perspective (p = 0.018). The psychosocial health summary and physical health summary scores also improved significantly after LARS. HRQoL before and after LARS was significantly lower in children with impaired neurodevelopment (p < 0.001). However, neurodevelopment did not influence the effect of LARS on HRQoL. The only significant predictor for improvement in HRQoL after LARS was age at the time of operation (p = 0.001).CONCLUSIONS: HRQoL significantly improves after LARS. Although children with impaired neurodevelopment had lower overall HRQoL, neurodevelopment by itself does not predict inferior improvement in HRQoL after LARS. Older children have a more favorable HRQoL outcome after LARS compared to younger children. This may suggest caution when considering LARS in younger GERD patients.

AB - INTRODUCTION: Improving health-related quality of life (HRQoL) is increasingly recognized as an essential part of patient care outcome. Little is known about the effect of laparoscopic antireflux surgery (LARS) on the HRQoL in the pediatric patients. The aims of this study were to evaluate the effect of LARS on HRQoL in children with gastroesophageal reflux disease (GERD) and to identify predictors that influence HRQoL outcome after LARS.METHODS: Between 2011 and 2013, 25 patients with therapy-resistant GERD [median age 6 (2-18) years] were included prospectively. Caregivers and children with normal neurodevelopment (>4 years) were asked to fill out the validated PedsQL 4.0 Generic Core Scales before and 3-4 months after LARS.RESULTS: The PedsQL was completed by all caregivers (n = 25) and 12 children. HRQoL total score improved significantly after LARS, both from a parental (p = 0.009) and child's perspective (p = 0.018). The psychosocial health summary and physical health summary scores also improved significantly after LARS. HRQoL before and after LARS was significantly lower in children with impaired neurodevelopment (p < 0.001). However, neurodevelopment did not influence the effect of LARS on HRQoL. The only significant predictor for improvement in HRQoL after LARS was age at the time of operation (p = 0.001).CONCLUSIONS: HRQoL significantly improves after LARS. Although children with impaired neurodevelopment had lower overall HRQoL, neurodevelopment by itself does not predict inferior improvement in HRQoL after LARS. Older children have a more favorable HRQoL outcome after LARS compared to younger children. This may suggest caution when considering LARS in younger GERD patients.

KW - Child

KW - Child, Preschool

KW - Female

KW - Fundoplication

KW - Gastroesophageal Reflux

KW - Health Status

KW - Humans

KW - Laparoscopy

KW - Male

KW - Prospective Studies

KW - Quality of Life

KW - Treatment Outcome

KW - Journal Article

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DO - 10.1007/s00464-016-5336-5

M3 - Article

VL - 31

SP - 3122

EP - 3129

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

IS - 8

ER -

Mauritz FA, Stellato RK, van Heurn LWE, Siersema PD, Sloots CEJ, Houwen RHJ et al. Laparoscopic antireflux surgery increases health-related quality of life in children with GERD. Surgical Endoscopy. 2017 Aug;31(8):3122-3129. https://doi.org/10.1007/s00464-016-5336-5