Late-life brain perfusion after prenatal famine exposure

Susanne R. de Rooij, Henri J. M. M. Mutsaerts, Jan Petr, Iris Asllani, Matthan W. A. Caan, Paul Groot, Aart J. Nederveen, Matthias Schwab, Tessa J. Roseboom

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Early nutritional deprivation may cause irreversible damage to the brain and seems to affect cognitive function in older age. We investigated whether prenatal undernutrition was associated with brain perfusion differences in older age. We acquired Arterial spin labeling scans in 118 Dutch famine birth cohort members. Using linear regression analyses, cerebral blood flow was compared between exposed and unexposed groups in gray matter (GM) and white matter (WM), perfusion territories, the neurodegeneration-related regions anterior and posterior cingulate cortex and precuneus. Furthermore, we compared the GM/WM ratio and the spatial coefficient of variation as a proxy of overall cerebrovascular health. The WM arterial spin labeling signal and the GM/WM ratio were significantly lower and higher, respectively, among exposed participants (−2.5 mL/100 g/min [95% CI: −4.3 to −0.8; p = 0.01] and 0.48 [0.19 to 0.76; p = 0.002], respectively). Exposed men had lower cerebral blood flow in anterior and posterior cingulate cortices (−8.0 mL/100 g/min [−15.1 to −0.9; p = 0.03]; −11.4 mL/100 g/min [−19.6 to −3.2; p = 0.02]) and higher spatial coefficient of variation (0.05 [0.00 to 0.09; p = 0.05]). The latter seemed largely mediated by higher 2h-glucose levels at age 50. Our findings suggest that prenatal undernutrition affects brain perfusion parameters providing further evidence for life-long effects of undernutrition during early brain development.
Original languageEnglish
Pages (from-to)1-9
JournalNeurobiology of Aging
Volume82
DOIs
Publication statusPublished - 1 Oct 2019
Externally publishedYes

Cite this

de Rooij, S. R., Mutsaerts, H. J. M. M., Petr, J., Asllani, I., Caan, M. W. A., Groot, P., ... Roseboom, T. J. (2019). Late-life brain perfusion after prenatal famine exposure. Neurobiology of Aging, 82, 1-9. https://doi.org/10.1016/j.neurobiolaging.2019.06.012
de Rooij, Susanne R. ; Mutsaerts, Henri J. M. M. ; Petr, Jan ; Asllani, Iris ; Caan, Matthan W. A. ; Groot, Paul ; Nederveen, Aart J. ; Schwab, Matthias ; Roseboom, Tessa J. / Late-life brain perfusion after prenatal famine exposure. In: Neurobiology of Aging. 2019 ; Vol. 82. pp. 1-9.
@article{50f95892fef14423a00ae526377b4dd7,
title = "Late-life brain perfusion after prenatal famine exposure",
abstract = "Early nutritional deprivation may cause irreversible damage to the brain and seems to affect cognitive function in older age. We investigated whether prenatal undernutrition was associated with brain perfusion differences in older age. We acquired Arterial spin labeling scans in 118 Dutch famine birth cohort members. Using linear regression analyses, cerebral blood flow was compared between exposed and unexposed groups in gray matter (GM) and white matter (WM), perfusion territories, the neurodegeneration-related regions anterior and posterior cingulate cortex and precuneus. Furthermore, we compared the GM/WM ratio and the spatial coefficient of variation as a proxy of overall cerebrovascular health. The WM arterial spin labeling signal and the GM/WM ratio were significantly lower and higher, respectively, among exposed participants (−2.5 mL/100 g/min [95{\%} CI: −4.3 to −0.8; p = 0.01] and 0.48 [0.19 to 0.76; p = 0.002], respectively). Exposed men had lower cerebral blood flow in anterior and posterior cingulate cortices (−8.0 mL/100 g/min [−15.1 to −0.9; p = 0.03]; −11.4 mL/100 g/min [−19.6 to −3.2; p = 0.02]) and higher spatial coefficient of variation (0.05 [0.00 to 0.09; p = 0.05]). The latter seemed largely mediated by higher 2h-glucose levels at age 50. Our findings suggest that prenatal undernutrition affects brain perfusion parameters providing further evidence for life-long effects of undernutrition during early brain development.",
author = "{de Rooij}, {Susanne R.} and Mutsaerts, {Henri J. M. M.} and Jan Petr and Iris Asllani and Caan, {Matthan W. A.} and Paul Groot and Nederveen, {Aart J.} and Matthias Schwab and Roseboom, {Tessa J.}",
year = "2019",
month = "10",
day = "1",
doi = "10.1016/j.neurobiolaging.2019.06.012",
language = "English",
volume = "82",
pages = "1--9",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

de Rooij, SR, Mutsaerts, HJMM, Petr, J, Asllani, I, Caan, MWA, Groot, P, Nederveen, AJ, Schwab, M & Roseboom, TJ 2019, 'Late-life brain perfusion after prenatal famine exposure' Neurobiology of Aging, vol. 82, pp. 1-9. https://doi.org/10.1016/j.neurobiolaging.2019.06.012

Late-life brain perfusion after prenatal famine exposure. / de Rooij, Susanne R.; Mutsaerts, Henri J. M. M.; Petr, Jan; Asllani, Iris; Caan, Matthan W. A.; Groot, Paul; Nederveen, Aart J.; Schwab, Matthias; Roseboom, Tessa J.

In: Neurobiology of Aging, Vol. 82, 01.10.2019, p. 1-9.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Late-life brain perfusion after prenatal famine exposure

AU - de Rooij, Susanne R.

AU - Mutsaerts, Henri J. M. M.

AU - Petr, Jan

AU - Asllani, Iris

AU - Caan, Matthan W. A.

AU - Groot, Paul

AU - Nederveen, Aart J.

AU - Schwab, Matthias

AU - Roseboom, Tessa J.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Early nutritional deprivation may cause irreversible damage to the brain and seems to affect cognitive function in older age. We investigated whether prenatal undernutrition was associated with brain perfusion differences in older age. We acquired Arterial spin labeling scans in 118 Dutch famine birth cohort members. Using linear regression analyses, cerebral blood flow was compared between exposed and unexposed groups in gray matter (GM) and white matter (WM), perfusion territories, the neurodegeneration-related regions anterior and posterior cingulate cortex and precuneus. Furthermore, we compared the GM/WM ratio and the spatial coefficient of variation as a proxy of overall cerebrovascular health. The WM arterial spin labeling signal and the GM/WM ratio were significantly lower and higher, respectively, among exposed participants (−2.5 mL/100 g/min [95% CI: −4.3 to −0.8; p = 0.01] and 0.48 [0.19 to 0.76; p = 0.002], respectively). Exposed men had lower cerebral blood flow in anterior and posterior cingulate cortices (−8.0 mL/100 g/min [−15.1 to −0.9; p = 0.03]; −11.4 mL/100 g/min [−19.6 to −3.2; p = 0.02]) and higher spatial coefficient of variation (0.05 [0.00 to 0.09; p = 0.05]). The latter seemed largely mediated by higher 2h-glucose levels at age 50. Our findings suggest that prenatal undernutrition affects brain perfusion parameters providing further evidence for life-long effects of undernutrition during early brain development.

AB - Early nutritional deprivation may cause irreversible damage to the brain and seems to affect cognitive function in older age. We investigated whether prenatal undernutrition was associated with brain perfusion differences in older age. We acquired Arterial spin labeling scans in 118 Dutch famine birth cohort members. Using linear regression analyses, cerebral blood flow was compared between exposed and unexposed groups in gray matter (GM) and white matter (WM), perfusion territories, the neurodegeneration-related regions anterior and posterior cingulate cortex and precuneus. Furthermore, we compared the GM/WM ratio and the spatial coefficient of variation as a proxy of overall cerebrovascular health. The WM arterial spin labeling signal and the GM/WM ratio were significantly lower and higher, respectively, among exposed participants (−2.5 mL/100 g/min [95% CI: −4.3 to −0.8; p = 0.01] and 0.48 [0.19 to 0.76; p = 0.002], respectively). Exposed men had lower cerebral blood flow in anterior and posterior cingulate cortices (−8.0 mL/100 g/min [−15.1 to −0.9; p = 0.03]; −11.4 mL/100 g/min [−19.6 to −3.2; p = 0.02]) and higher spatial coefficient of variation (0.05 [0.00 to 0.09; p = 0.05]). The latter seemed largely mediated by higher 2h-glucose levels at age 50. Our findings suggest that prenatal undernutrition affects brain perfusion parameters providing further evidence for life-long effects of undernutrition during early brain development.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069921167&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31376728

U2 - 10.1016/j.neurobiolaging.2019.06.012

DO - 10.1016/j.neurobiolaging.2019.06.012

M3 - Article

VL - 82

SP - 1

EP - 9

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -