TY - JOUR
T1 - Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease
AU - Villeneuve, Sarah-Christine
AU - Houot, Marion
AU - Cacciamani, Federica
AU - Verrijp, Merike
AU - Dubois, Bruno
AU - Sikkes, Sietske
AU - Epelbaum, Stéphane
AU - Bakardjian, Hovagim
AU - Benali, Habib
AU - Bertin, Hugo
AU - LaurieBoukadida, Joel Bonheur
AU - Boukerrou, Nadia
AU - Cavedo, Enrica
AU - Chiesa, Patrizia
AU - Colliot, Olivier
AU - MEMENTO study group and the INSIGHT-preAD study group
AU - Dubois, Marion
AU - Gagliardi, Geoffroy
AU - Genthon, Remy
AU - Habert, Marie-Odile
AU - Hampel, Harald
AU - Kas, Aurélie
AU - Lamari, Foudil
AU - Levy, Marcel
AU - Lista, Simone
AU - Metzinger, Christiane
AU - Mochel, Fanny
AU - Nyasse, Francis
AU - Poisson, Catherine
AU - Potier, Marie-Claude
AU - Revillon, Marie
AU - Santos, Antonio
AU - Andrade, Katia Santos
AU - Sole, Marine
AU - Surtee, Mohmed
AU - Thiebaud de Schotten, Michel
AU - Vergallo, Andrea
AU - Younsi, Nadjia
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Introduction: Trials in Alzheimer's disease (AD) now include participants at the earliest stages to prevent further decline. However, the lack of tools sensitive to subtle functional changes in early-stage AD hinders the development of new therapies as it is difficult to prove their clinical relevance. Methods: We assessed functional changes over three years in 289 elderly memory complainers from the Investigation of Alzheimer's Predictors in subjective memory complainers cohort using the Amsterdam Instrumental-Activities-of-Daily-Living questionnaire (A-IADL-Q). Results: No overall functional decline related to AD imaging markers was evidenced. However, five distinct classes of A-IADL-Q trajectories were identified. The largest class (212 [73.4%]) had stable A-IADL-Q scores over 3 years. A second group (23 [8.0%]) showed a persistent functional decline, higher amyloid load (P =.0005), and lower education (P =.0392). Discussion: The A-IADL-Q identified a subtle functional decline in asymptomatic at-risk AD individuals. This could have important implications in the field of early intervention in AD.
AB - Introduction: Trials in Alzheimer's disease (AD) now include participants at the earliest stages to prevent further decline. However, the lack of tools sensitive to subtle functional changes in early-stage AD hinders the development of new therapies as it is difficult to prove their clinical relevance. Methods: We assessed functional changes over three years in 289 elderly memory complainers from the Investigation of Alzheimer's Predictors in subjective memory complainers cohort using the Amsterdam Instrumental-Activities-of-Daily-Living questionnaire (A-IADL-Q). Results: No overall functional decline related to AD imaging markers was evidenced. However, five distinct classes of A-IADL-Q trajectories were identified. The largest class (212 [73.4%]) had stable A-IADL-Q scores over 3 years. A second group (23 [8.0%]) showed a persistent functional decline, higher amyloid load (P =.0005), and lower education (P =.0392). Discussion: The A-IADL-Q identified a subtle functional decline in asymptomatic at-risk AD individuals. This could have important implications in the field of early intervention in AD.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072989632&origin=inward
U2 - 10.1016/j.trci.2019.08.009
DO - 10.1016/j.trci.2019.08.009
M3 - Article
C2 - 31650012
VL - 5
SP - 553
EP - 562
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
SN - 2352-8737
ER -