Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease

Sarah-Christine Villeneuve, Marion Houot, Federica Cacciamani, Merike Verrijp, Bruno Dubois, Sietske Sikkes, Stéphane Epelbaum, Hovagim Bakardjian, Habib Benali, Hugo Bertin, Joel Bonheur LaurieBoukadida, Nadia Boukerrou, Enrica Cavedo, Patrizia Chiesa, Olivier Colliot, MEMENTO study group and the INSIGHT-preAD study group, Marion Dubois, Geoffroy Gagliardi, Remy Genthon, Marie-Odile HabertHarald Hampel, Aurélie Kas, Foudil Lamari, Marcel Levy, Simone Lista, Christiane Metzinger, Fanny Mochel, Francis Nyasse, Catherine Poisson, Marie-Claude Potier, Marie Revillon, Antonio Santos, Katia Santos Andrade, Marine Sole, Mohmed Surtee, Michel Thiebaud de Schotten, Andrea Vergallo, Nadjia Younsi

Research output: Contribution to journalArticleAcademicpeer-review


Introduction: Trials in Alzheimer's disease (AD) now include participants at the earliest stages to prevent further decline. However, the lack of tools sensitive to subtle functional changes in early-stage AD hinders the development of new therapies as it is difficult to prove their clinical relevance. Methods: We assessed functional changes over three years in 289 elderly memory complainers from the Investigation of Alzheimer's Predictors in subjective memory complainers cohort using the Amsterdam Instrumental-Activities-of-Daily-Living questionnaire (A-IADL-Q). Results: No overall functional decline related to AD imaging markers was evidenced. However, five distinct classes of A-IADL-Q trajectories were identified. The largest class (212 [73.4%]) had stable A-IADL-Q scores over 3 years. A second group (23 [8.0%]) showed a persistent functional decline, higher amyloid load (P =.0005), and lower education (P =.0392). Discussion: The A-IADL-Q identified a subtle functional decline in asymptomatic at-risk AD individuals. This could have important implications in the field of early intervention in AD.
Original languageEnglish
Pages (from-to)553-562
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Publication statusPublished - 1 Jan 2019

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