Leukocyte adhesion deficiencies

Edith van de Vijver, Timo K van den Berg, Taco W Kuijpers

Research output: Contribution to journalReview articleAcademicpeer-review


During inflammation, leukocytes play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. Leukocyte adhesion deficiencies (ie, LAD-I, -II, and LAD-I/variant, the latter also known as LAD-III) are caused by defects in the adhesion of leukocytes to the vessel wall, resulting in severe recurrent nonpussing infections and neutrophilia, often preceded by delayed separation of the umbilical cord. Although dependent on the genetic defect, hematopoietic stem cell transplantation is often the only curative treatment.

Original languageEnglish
Pages (from-to)101-16, viii
JournalHematology/Oncology Clinics of North America
Issue number1
Publication statusPublished - Feb 2013

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