TY - JOUR
T1 - Lifespan normative data on rates of brain volume changes
AU - Battaglini, Marco
AU - Gentile, Giordano
AU - Luchetti, Ludovico
AU - Giorgio, Antonio
AU - Vrenken, Hugo
AU - Barkhof, Frederik
AU - Cover, Keith S.
AU - Bakshi, Rohit
AU - Chu, Renxin
AU - Sormani, Maria Pia
AU - Enzinger, Christian
AU - Ropele, Stefan
AU - Ciccarelli, Olga
AU - Wheeler-Kingshott, Claudia
AU - Yiannakas, Marios
AU - Filippi, Massimo
AU - Rocca, Maria Assunta
AU - Preziosa, Paolo
AU - Gallo, Antonio
AU - Bisecco, Alvino
AU - Palace, Jacqueline
AU - Kong, Yazhuo
AU - Horakova, Dana
AU - Vaneckova, Manuela
AU - Gasperini, Claudio
AU - Ruggeri, Serena
AU - de Stefano, Nicola
AU - MAGNIMS Study Group
PY - 2019/9/1
Y1 - 2019/9/1
N2 - We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16–90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30–40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting.
AB - We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16–90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30–40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067179408&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31207467
U2 - 10.1016/j.neurobiolaging.2019.05.010
DO - 10.1016/j.neurobiolaging.2019.05.010
M3 - Article
C2 - 31207467
VL - 81
SP - 30
EP - 37
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -