Lifespan normative data on rates of brain volume changes

Marco Battaglini, Giordano Gentile, Ludovico Luchetti, Antonio Giorgio, Hugo Vrenken, Frederik Barkhof, Keith S. Cover, Rohit Bakshi, Renxin Chu, Maria Pia Sormani, Christian Enzinger, Stefan Ropele, Olga Ciccarelli, Claudia Wheeler-Kingshott, Marios Yiannakas, Massimo Filippi, Maria Assunta Rocca, Paolo Preziosa, Antonio Gallo, Alvino BiseccoJacqueline Palace, Yazhuo Kong, Dana Horakova, Manuela Vaneckova, Claudio Gasperini, Serena Ruggeri, Nicola de Stefano, MAGNIMS Study Group

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Abstract

We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16–90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30–40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting.
Original languageEnglish
Pages (from-to)30-37
JournalNeurobiology of Aging
Volume81
DOIs
Publication statusPublished - 1 Sep 2019

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