Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma

Tuna Toptan, Marion G Brusadelli, Brian Turpin, David P Witte, Jordi Surrallés, Eunike Velleuer, Martin Schramm, Ralf Dietrich, Ruud H Brakenhoff, Patrick S Moore, Yuan Chang, Susanne I Wells

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Abstract

Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.

Original languageEnglish
Pages (from-to)e0209235
JournalPLoS ONE
Volume13
Issue number12
DOIs
Publication statusPublished - 2018

Cite this

Toptan, T., Brusadelli, M. G., Turpin, B., Witte, D. P., Surrallés, J., Velleuer, E., ... Wells, S. I. (2018). Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma. PLoS ONE, 13(12), e0209235. https://doi.org/10.1371/journal.pone.0209235