Liquid biopsies come of age: Towards implementation of circulating tumour DNA

Jonathan C.M. Wan, Charles Massie, Javier Garcia-Corbacho, Florent Mouliere, James D. Brenton, Carlos Caldas, Simon Pacey, Richard Baird, Nitzan Rosenfeld*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and monitoring. The field is now in an exciting transitional period in which ctDNA analysis is beginning to be applied clinically, although there is still much to learn about the biology of cell-free DNA. This is an opportune time to appraise potential approaches to ctDNA analysis, and to consider their applications in personalized oncology and in cancer research.

Original languageEnglish
Pages (from-to)223-238
Number of pages16
JournalNature Reviews Cancer
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017

Cite this

Wan, J. C. M., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J. D., Caldas, C., ... Rosenfeld, N. (2017). Liquid biopsies come of age: Towards implementation of circulating tumour DNA. Nature Reviews Cancer, 17(4), 223-238. https://doi.org/10.1038/nrc.2017.7