Local immunomodulation for cancer therapy: Providing treatment where needed

Marieke F. Fransen, Ferry Ossendorp, Ramon Arens, Cornelis J. M. Melief

Research output: Contribution to journalArticleAcademicpeer-review


In murine models of cancer, we have achieved efficient systemic activation of tumor-specific T cells by the local administration of a CTLA4-blocking antibody at low doses. Using a slow-release formulation, we could drastically lower the serum levels of the antibody, hence decreasing adverse effects and the risk of autoimmune reactions, without losing systemic efficacy. © 2013 Landes Bioscience.
Original languageEnglish
Article numbere26493
Issue number11
Publication statusPublished - 2013
Externally publishedYes

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