Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis

A Baidoshvili, R Nijmeijer, W K Lagrand, C E Hack, H W M Niessen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.

Original languageEnglish
Pages (from-to)152-3
Number of pages2
JournalJournal of Clinical Pathology
Volume55
Issue number2
Publication statusPublished - Feb 2002

Cite this

Baidoshvili, A ; Nijmeijer, R ; Lagrand, W K ; Hack, C E ; Niessen, H W M. / Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis. In: Journal of Clinical Pathology. 2002 ; Vol. 55, No. 2. pp. 152-3.
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abstract = "This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.",
keywords = "C-Reactive Protein, Fatal Outcome, Female, Humans, Infarction, Kidney, Liver, Middle Aged, Sepsis, Case Reports, Journal Article, Research Support, Non-U.S. Gov't",
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Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis. / Baidoshvili, A; Nijmeijer, R; Lagrand, W K; Hack, C E; Niessen, H W M.

In: Journal of Clinical Pathology, Vol. 55, No. 2, 02.2002, p. 152-3.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis

AU - Baidoshvili, A

AU - Nijmeijer, R

AU - Lagrand, W K

AU - Hack, C E

AU - Niessen, H W M

PY - 2002/2

Y1 - 2002/2

N2 - This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.

AB - This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.

KW - C-Reactive Protein

KW - Fatal Outcome

KW - Female

KW - Humans

KW - Infarction

KW - Kidney

KW - Liver

KW - Middle Aged

KW - Sepsis

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

VL - 55

SP - 152

EP - 153

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

SN - 0021-9746

IS - 2

ER -