Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis

A Baidoshvili, R Nijmeijer, W K Lagrand, C E Hack, H W M Niessen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.

Original languageEnglish
Pages (from-to)152-3
Number of pages2
JournalJournal of Clinical Pathology
Volume55
Issue number2
Publication statusPublished - Feb 2002

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