TY - JOUR
T1 - Localization of beta 1 integrins and their extracellular ligands in human lymphoid tissues
AU - van den Berg, T K
AU - van der Ende, M
AU - Döpp, E A
AU - Kraal, G
AU - Dijkstra, C D
PY - 1993/10
Y1 - 1993/10
N2 - In this study, we describe the immunocytochemical distribution of the beta 1 integrins (alpha 1 to alpha 6) and their extracellular matrix ligands in human peripheral lymphoid tissues. The results show that within these tissues individual beta 1 integrins are differentially expressed by (sub)populations of stromal cells, including reticular cells, endothelial cells, epithelial cells, and sinus lining cells. The extracellular matrix components studied, eg, collagen I, III, and VI, fibronectin, laminin, and vitronectin, were predominantly associated with the stroma of the lymphoid tissues, and a unique distribution pattern was observed for each of them. Except for alpha 4 (and beta 1), low or no expression of the beta 1 integrins was found on lymphocytes, macrophages, interdigitating cells, and follicular dendritic cells. The results suggest that cell-matrix interactions play a major role in the maintenance of the complex spatial organization of the lymphoid tissue.
AB - In this study, we describe the immunocytochemical distribution of the beta 1 integrins (alpha 1 to alpha 6) and their extracellular matrix ligands in human peripheral lymphoid tissues. The results show that within these tissues individual beta 1 integrins are differentially expressed by (sub)populations of stromal cells, including reticular cells, endothelial cells, epithelial cells, and sinus lining cells. The extracellular matrix components studied, eg, collagen I, III, and VI, fibronectin, laminin, and vitronectin, were predominantly associated with the stroma of the lymphoid tissues, and a unique distribution pattern was observed for each of them. Except for alpha 4 (and beta 1), low or no expression of the beta 1 integrins was found on lymphocytes, macrophages, interdigitating cells, and follicular dendritic cells. The results suggest that cell-matrix interactions play a major role in the maintenance of the complex spatial organization of the lymphoid tissue.
KW - Child
KW - Child, Preschool
KW - Collagen/metabolism
KW - Extracellular Matrix Proteins/metabolism
KW - Extracellular Space/metabolism
KW - Fibronectins/metabolism
KW - Glycoproteins/metabolism
KW - Humans
KW - Integrins/chemistry
KW - Laminin/metabolism
KW - Ligands
KW - Lymphoid Tissue/metabolism
KW - Peptide Fragments/metabolism
KW - Tissue Distribution
KW - Vitronectin
M3 - Article
C2 - 7692731
VL - 143
SP - 1098
EP - 1110
JO - The American Journal of Pathology
JF - The American Journal of Pathology
SN - 0002-9440
IS - 4
ER -