Long-lasting reciprocal changes in striatal dopamine and acetylcholine release upon morphine withdrawal

H. K. Guno Tjon Tien Ril, Taco J. De Vries, George Wardeh, Francois Hogenboom, Arie H. Mulder, Anton N M Schoffelmeer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In superfused rat striatal slices, the electrically evoked release of [3]dopamine was reduced by about 30% and that of [14C]acetylcholine was enhanced by about 25% no less than 3 weeks after morphine withdrawal in rats chronically treated with the opiate for 6 days. The lasting nature of the reduced dopamine release at the level of dopaminergic nerve terminals and the concomittant enhanced excitability of neurons tonically inhibited by released dopamine, such as cholinergic interneurons, could play an important role in the maintenance of opiate dependence.

Original languageEnglish
Pages (from-to)321-322
Number of pages2
JournalEuropean Journal of Pharmacology
Volume235
Issue number2-3
DOIs
Publication statusPublished - 28 Apr 1993

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