Long non-coding RNA in vascular disease and aging

Diewertje I. Bink, Noelia Lozano-Vidal, Reinier A. Boon

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Cardiovascular diseases are the most prominent cause of death inWestern society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.
Original languageEnglish
Article number26
JournalNon-coding RNA
Volume5
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Cite this

@article{6e3fc747f70e41519bdd21adea666ed3,
title = "Long non-coding RNA in vascular disease and aging",
abstract = "Cardiovascular diseases are the most prominent cause of death inWestern society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.",
keywords = "Aging, LncRNA, Vascular disease",
author = "Bink, {Diewertje I.} and Noelia Lozano-Vidal and Boon, {Reinier A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.3390/ncrna5010026",
language = "English",
volume = "5",
journal = "Non-coding RNA",
issn = "2311-553X",
publisher = "MDPI AG",
number = "1",

}

Long non-coding RNA in vascular disease and aging. / Bink, Diewertje I.; Lozano-Vidal, Noelia; Boon, Reinier A.

In: Non-coding RNA, Vol. 5, No. 1, 26, 01.01.2019.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Long non-coding RNA in vascular disease and aging

AU - Bink, Diewertje I.

AU - Lozano-Vidal, Noelia

AU - Boon, Reinier A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Cardiovascular diseases are the most prominent cause of death inWestern society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.

AB - Cardiovascular diseases are the most prominent cause of death inWestern society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.

KW - Aging

KW - LncRNA

KW - Vascular disease

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063961483&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30893946

U2 - 10.3390/ncrna5010026

DO - 10.3390/ncrna5010026

M3 - Review article

VL - 5

JO - Non-coding RNA

JF - Non-coding RNA

SN - 2311-553X

IS - 1

M1 - 26

ER -