Abstract
Original language | English |
---|---|
Pages (from-to) | 402-410 |
Journal | Brain Imaging and Behavior |
Volume | 12 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2018 |
Externally published | Yes |
Cite this
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Long-term effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attention-deficit hyperactivity disorder. / Schrantee, Anouk; Bouziane, C.; Bron, E. E.; Klein, S.; Bottelier, M. A.; Kooij, J. J. S.; Rombouts, S. A. R. B.; Reneman, L.
In: Brain Imaging and Behavior, Vol. 12, No. 2, 2018, p. 402-410.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Long-term effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attention-deficit hyperactivity disorder
AU - Schrantee, Anouk
AU - Bouziane, C.
AU - Bron, E. E.
AU - Klein, S.
AU - Bottelier, M. A.
AU - Kooij, J. J. S.
AU - Rombouts, S. A. R. B.
AU - Reneman, L.
PY - 2018
Y1 - 2018
N2 - Stimulant prescription rates for attention deficit hyperactivity disorder (ADHD) are increasing, even though potential long-term effects on the developing brain have not been well-studied. A previous randomized clinical trial showed short-term age-dependent effects of stimulants on the DA system. We here assessed the long-term modifying effects of age-of-first-stimulant treatment on the human brain and behavior. 81 male adult ADHD patients were stratified into three groups: 1) early stimulant treatment (EST; <16 years of age) 2) late stimulant treatment (LST: ≥23 years of age) and 3) stimulant treatment naive (STN; no history of stimulant treatment). We used pharmacological magnetic resonance imaging (phMRI) to assess the cerebral blood flow (CBF) response to an oral methylphenidate challenge (MPH, 0.5 mg/kg), as an indirect measure of dopamine function in fronto-striatal areas. In addition, mood and anxiety scores, and recreational drug use were assessed. Baseline ACC CBF was lower in the EST than the STN group (p = 0.03), although CBF response to MPH was similar between the three groups (p = 0.23). ADHD symptom severity was higher in the STN group compared to the other groups (p < 0.01). In addition, the EST group reported more depressive symptoms (p = 0.04), but not anxiety (p = 0.26), and less recreational drug use (p = 0.04). In line with extensive pre-clinical data, our data suggest that early, but not late, stimulant treatment long-lastingly affects the human brain and behavior, possibly indicating fundamental changes in the dopamine system.
AB - Stimulant prescription rates for attention deficit hyperactivity disorder (ADHD) are increasing, even though potential long-term effects on the developing brain have not been well-studied. A previous randomized clinical trial showed short-term age-dependent effects of stimulants on the DA system. We here assessed the long-term modifying effects of age-of-first-stimulant treatment on the human brain and behavior. 81 male adult ADHD patients were stratified into three groups: 1) early stimulant treatment (EST; <16 years of age) 2) late stimulant treatment (LST: ≥23 years of age) and 3) stimulant treatment naive (STN; no history of stimulant treatment). We used pharmacological magnetic resonance imaging (phMRI) to assess the cerebral blood flow (CBF) response to an oral methylphenidate challenge (MPH, 0.5 mg/kg), as an indirect measure of dopamine function in fronto-striatal areas. In addition, mood and anxiety scores, and recreational drug use were assessed. Baseline ACC CBF was lower in the EST than the STN group (p = 0.03), although CBF response to MPH was similar between the three groups (p = 0.23). ADHD symptom severity was higher in the STN group compared to the other groups (p < 0.01). In addition, the EST group reported more depressive symptoms (p = 0.04), but not anxiety (p = 0.26), and less recreational drug use (p = 0.04). In line with extensive pre-clinical data, our data suggest that early, but not late, stimulant treatment long-lastingly affects the human brain and behavior, possibly indicating fundamental changes in the dopamine system.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015669337&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28321605
U2 - 10.1007/s11682-017-9707-x
DO - 10.1007/s11682-017-9707-x
M3 - Article
VL - 12
SP - 402
EP - 410
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
IS - 2
ER -