Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders

Lotte Gerritsen, Sabine M. Staufenbiel, Brenda W. J. H. Penninx, Albert M. van Hemert, Gerard Noppe, Yolanda B. de Rijke, Elisabeth F. C. van Rossum

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Depressive and anxiety disorders have been linked to a dysregulated hypothalamus-pituitary-adrenal (HPA)-axis. Hair cortisol levels (HairF) reflect integrated long-term cortisol regulation and are therefore promising endocrine markers of chronic (psychological and physical) stress. Our aim was to assess hair cortisol levels in persons with a depressive and/or anxiety disorder and to compare their levels with that of persons in remission and healthy controls. Methods: Data from 1166 participants of the Netherlands Study of Depression and Anxiety (NESDA) were used, including 266 participants with a recent (1-month) diagnosis of a depressive and/or anxiety disorder, 655 participants with a diagnosis in remission, and 245 healthy controls. HairF was measured in the proximal three cm of scalp hair, using LC–MS/MS. Results: Compared to the healthy controls no differences on HairF or HairE levels were found for depressive and anxiety disorders alone. However the presence of a comorbid depressive and anxiety disorder was significantly associated with increased HairF levels (β = 0.07; p =.031), as was the severity of depressive symptoms (β = 0.06; p =.029), but no differences were found on HairE nor the HairF:HairE ratio. Conclusions: Persons with current diagnosis of comorbid depression and anxiety show moderately higher levels of cortisol than patients with only depression or anxiety, or patients in remission and healthy controls, which may be indicative of a chronic state of hyperactivation of the HPA axis.
LanguageEnglish
Pages246-252
JournalPsychoneuroendocrinology
Volume101
DOIs
StatePublished - 2019

Cite this

Gerritsen, L., Staufenbiel, S. M., Penninx, B. W. J. H., van Hemert, A. M., Noppe, G., de Rijke, Y. B., & van Rossum, E. F. C. (2019). Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders. Psychoneuroendocrinology, 101, 246-252. DOI: 10.1016/j.psyneuen.2018.11.019
Gerritsen, Lotte ; Staufenbiel, Sabine M. ; Penninx, Brenda W. J. H. ; van Hemert, Albert M. ; Noppe, Gerard ; de Rijke, Yolanda B. ; van Rossum, Elisabeth F. C./ Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders. In: Psychoneuroendocrinology. 2019 ; Vol. 101. pp. 246-252
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title = "Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders",
abstract = "Background: Depressive and anxiety disorders have been linked to a dysregulated hypothalamus-pituitary-adrenal (HPA)-axis. Hair cortisol levels (HairF) reflect integrated long-term cortisol regulation and are therefore promising endocrine markers of chronic (psychological and physical) stress. Our aim was to assess hair cortisol levels in persons with a depressive and/or anxiety disorder and to compare their levels with that of persons in remission and healthy controls. Methods: Data from 1166 participants of the Netherlands Study of Depression and Anxiety (NESDA) were used, including 266 participants with a recent (1-month) diagnosis of a depressive and/or anxiety disorder, 655 participants with a diagnosis in remission, and 245 healthy controls. HairF was measured in the proximal three cm of scalp hair, using LC–MS/MS. Results: Compared to the healthy controls no differences on HairF or HairE levels were found for depressive and anxiety disorders alone. However the presence of a comorbid depressive and anxiety disorder was significantly associated with increased HairF levels (β = 0.07; p =.031), as was the severity of depressive symptoms (β = 0.06; p =.029), but no differences were found on HairE nor the HairF:HairE ratio. Conclusions: Persons with current diagnosis of comorbid depression and anxiety show moderately higher levels of cortisol than patients with only depression or anxiety, or patients in remission and healthy controls, which may be indicative of a chronic state of hyperactivation of the HPA axis.",
author = "Lotte Gerritsen and Staufenbiel, {Sabine M.} and Penninx, {Brenda W. J. H.} and {van Hemert}, {Albert M.} and Gerard Noppe and {de Rijke}, {Yolanda B.} and {van Rossum}, {Elisabeth F. C.}",
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Gerritsen, L, Staufenbiel, SM, Penninx, BWJH, van Hemert, AM, Noppe, G, de Rijke, YB & van Rossum, EFC 2019, 'Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders' Psychoneuroendocrinology, vol. 101, pp. 246-252. DOI: 10.1016/j.psyneuen.2018.11.019

Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders. / Gerritsen, Lotte; Staufenbiel, Sabine M.; Penninx, Brenda W. J. H.; van Hemert, Albert M.; Noppe, Gerard; de Rijke, Yolanda B.; van Rossum, Elisabeth F. C.

In: Psychoneuroendocrinology, Vol. 101, 2019, p. 246-252.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders

AU - Gerritsen,Lotte

AU - Staufenbiel,Sabine M.

AU - Penninx,Brenda W. J. H.

AU - van Hemert,Albert M.

AU - Noppe,Gerard

AU - de Rijke,Yolanda B.

AU - van Rossum,Elisabeth F. C.

PY - 2019

Y1 - 2019

N2 - Background: Depressive and anxiety disorders have been linked to a dysregulated hypothalamus-pituitary-adrenal (HPA)-axis. Hair cortisol levels (HairF) reflect integrated long-term cortisol regulation and are therefore promising endocrine markers of chronic (psychological and physical) stress. Our aim was to assess hair cortisol levels in persons with a depressive and/or anxiety disorder and to compare their levels with that of persons in remission and healthy controls. Methods: Data from 1166 participants of the Netherlands Study of Depression and Anxiety (NESDA) were used, including 266 participants with a recent (1-month) diagnosis of a depressive and/or anxiety disorder, 655 participants with a diagnosis in remission, and 245 healthy controls. HairF was measured in the proximal three cm of scalp hair, using LC–MS/MS. Results: Compared to the healthy controls no differences on HairF or HairE levels were found for depressive and anxiety disorders alone. However the presence of a comorbid depressive and anxiety disorder was significantly associated with increased HairF levels (β = 0.07; p =.031), as was the severity of depressive symptoms (β = 0.06; p =.029), but no differences were found on HairE nor the HairF:HairE ratio. Conclusions: Persons with current diagnosis of comorbid depression and anxiety show moderately higher levels of cortisol than patients with only depression or anxiety, or patients in remission and healthy controls, which may be indicative of a chronic state of hyperactivation of the HPA axis.

AB - Background: Depressive and anxiety disorders have been linked to a dysregulated hypothalamus-pituitary-adrenal (HPA)-axis. Hair cortisol levels (HairF) reflect integrated long-term cortisol regulation and are therefore promising endocrine markers of chronic (psychological and physical) stress. Our aim was to assess hair cortisol levels in persons with a depressive and/or anxiety disorder and to compare their levels with that of persons in remission and healthy controls. Methods: Data from 1166 participants of the Netherlands Study of Depression and Anxiety (NESDA) were used, including 266 participants with a recent (1-month) diagnosis of a depressive and/or anxiety disorder, 655 participants with a diagnosis in remission, and 245 healthy controls. HairF was measured in the proximal three cm of scalp hair, using LC–MS/MS. Results: Compared to the healthy controls no differences on HairF or HairE levels were found for depressive and anxiety disorders alone. However the presence of a comorbid depressive and anxiety disorder was significantly associated with increased HairF levels (β = 0.07; p =.031), as was the severity of depressive symptoms (β = 0.06; p =.029), but no differences were found on HairE nor the HairF:HairE ratio. Conclusions: Persons with current diagnosis of comorbid depression and anxiety show moderately higher levels of cortisol than patients with only depression or anxiety, or patients in remission and healthy controls, which may be indicative of a chronic state of hyperactivation of the HPA axis.

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Gerritsen L, Staufenbiel SM, Penninx BWJH, van Hemert AM, Noppe G, de Rijke YB et al. Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders. Psychoneuroendocrinology. 2019;101:246-252. Available from, DOI: 10.1016/j.psyneuen.2018.11.019