Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma

Marloes Nies, Mariëlle S.Klein Hesselink, Gea A. Huizinga, Esther Sulkers, Adrienne H. Brouwers, Johannes G.M. Burgerhof, Eveline W.C.M. Van Dam, Bas Havekes, Marry M. Van Den Heuvel-Eibrink, Eleonora P.M. Corssmit, Leontien C.M. Kremer, Romana T. Netea-Maier, Heleen J.H. Van Der Pal, Robin P. Peeters, John T.M. Plukker, Cécile M. Ronckers, Hanneke M. Van Santen, Wim J.E. Tissing, Thera P. Links*, Gianni Bocca

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. Design: Survivors diagnosed between 1970 and 2013 at age #18 years, were included. Exclusion criteria were a follow-up ,5 years, attained age ,18 years, or diagnosis of DTC as a second malignant neoplasm (SMN). Controls were matched by age, sex, and socioeconomic status. Survivors and controls were asked to complete 3 questionnaires [Short-Form 36 (HRQoL), Multidimensional Fatigue Inventory 20 (fatigue), and Hospital Anxiety and Depression Scale (anxiety/depression)]. Survivors completed a thyroid cancer-specific HRQoL questionnaire. Results: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7).Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL. Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.

Original languageEnglish
Pages (from-to)1218-1226
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
Publication statusPublished - 1 Apr 2017

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