Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma

Marloes Nies, Mariëlle S.Klein Hesselink, Gea A. Huizinga, Esther Sulkers, Adrienne H. Brouwers, Johannes G.M. Burgerhof, Eveline W.C.M. Van Dam, Bas Havekes, Marry M. Van Den Heuvel-Eibrink, Eleonora P.M. Corssmit, Leontien C.M. Kremer, Romana T. Netea-Maier, Heleen J.H. Van Der Pal, Robin P. Peeters, John T.M. Plukker, Cécile M. Ronckers, Hanneke M. Van Santen, Wim J.E. Tissing, Thera P. Links, Gianni Bocca

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. Design: Survivors diagnosed between 1970 and 2013 at age #18 years, were included. Exclusion criteria were a follow-up ,5 years, attained age ,18 years, or diagnosis of DTC as a second malignant neoplasm (SMN). Controls were matched by age, sex, and socioeconomic status. Survivors and controls were asked to complete 3 questionnaires [Short-Form 36 (HRQoL), Multidimensional Fatigue Inventory 20 (fatigue), and Hospital Anxiety and Depression Scale (anxiety/depression)]. Survivors completed a thyroid cancer-specific HRQoL questionnaire. Results: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7).Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL. Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.

Original languageEnglish
Pages (from-to)1218-1226
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume102
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017

Cite this

Nies, M., Hesselink, M. S. K., Huizinga, G. A., Sulkers, E., Brouwers, A. H., Burgerhof, J. G. M., ... Bocca, G. (2017). Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 102(4), 1218-1226. https://doi.org/10.1210/jc.2016-2246
Nies, Marloes ; Hesselink, Mariëlle S.Klein ; Huizinga, Gea A. ; Sulkers, Esther ; Brouwers, Adrienne H. ; Burgerhof, Johannes G.M. ; Van Dam, Eveline W.C.M. ; Havekes, Bas ; Van Den Heuvel-Eibrink, Marry M. ; Corssmit, Eleonora P.M. ; Kremer, Leontien C.M. ; Netea-Maier, Romana T. ; Van Der Pal, Heleen J.H. ; Peeters, Robin P. ; Plukker, John T.M. ; Ronckers, Cécile M. ; Van Santen, Hanneke M. ; Tissing, Wim J.E. ; Links, Thera P. ; Bocca, Gianni. / Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma. In: Journal of Clinical Endocrinology and Metabolism. 2017 ; Vol. 102, No. 4. pp. 1218-1226.
@article{323292ac1f67480fb9ee6f9841ee1df1,
title = "Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma",
abstract = "Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. Design: Survivors diagnosed between 1970 and 2013 at age #18 years, were included. Exclusion criteria were a follow-up ,5 years, attained age ,18 years, or diagnosis of DTC as a second malignant neoplasm (SMN). Controls were matched by age, sex, and socioeconomic status. Survivors and controls were asked to complete 3 questionnaires [Short-Form 36 (HRQoL), Multidimensional Fatigue Inventory 20 (fatigue), and Hospital Anxiety and Depression Scale (anxiety/depression)]. Survivors completed a thyroid cancer-specific HRQoL questionnaire. Results: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7).Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL. Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.",
author = "Marloes Nies and Hesselink, {Mari{\"e}lle S.Klein} and Huizinga, {Gea A.} and Esther Sulkers and Brouwers, {Adrienne H.} and Burgerhof, {Johannes G.M.} and {Van Dam}, {Eveline W.C.M.} and Bas Havekes and {Van Den Heuvel-Eibrink}, {Marry M.} and Corssmit, {Eleonora P.M.} and Kremer, {Leontien C.M.} and Netea-Maier, {Romana T.} and {Van Der Pal}, {Heleen J.H.} and Peeters, {Robin P.} and Plukker, {John T.M.} and Ronckers, {C{\'e}cile M.} and {Van Santen}, {Hanneke M.} and Tissing, {Wim J.E.} and Links, {Thera P.} and Gianni Bocca",
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language = "English",
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journal = "Journal of Clinical Endocrinology and Metabolism",
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Nies, M, Hesselink, MSK, Huizinga, GA, Sulkers, E, Brouwers, AH, Burgerhof, JGM, Van Dam, EWCM, Havekes, B, Van Den Heuvel-Eibrink, MM, Corssmit, EPM, Kremer, LCM, Netea-Maier, RT, Van Der Pal, HJH, Peeters, RP, Plukker, JTM, Ronckers, CM, Van Santen, HM, Tissing, WJE, Links, TP & Bocca, G 2017, 'Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma' Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 4, pp. 1218-1226. https://doi.org/10.1210/jc.2016-2246

Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma. / Nies, Marloes; Hesselink, Mariëlle S.Klein; Huizinga, Gea A.; Sulkers, Esther; Brouwers, Adrienne H.; Burgerhof, Johannes G.M.; Van Dam, Eveline W.C.M.; Havekes, Bas; Van Den Heuvel-Eibrink, Marry M.; Corssmit, Eleonora P.M.; Kremer, Leontien C.M.; Netea-Maier, Romana T.; Van Der Pal, Heleen J.H.; Peeters, Robin P.; Plukker, John T.M.; Ronckers, Cécile M.; Van Santen, Hanneke M.; Tissing, Wim J.E.; Links, Thera P.; Bocca, Gianni.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 102, No. 4, 01.04.2017, p. 1218-1226.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma

AU - Nies, Marloes

AU - Hesselink, Mariëlle S.Klein

AU - Huizinga, Gea A.

AU - Sulkers, Esther

AU - Brouwers, Adrienne H.

AU - Burgerhof, Johannes G.M.

AU - Van Dam, Eveline W.C.M.

AU - Havekes, Bas

AU - Van Den Heuvel-Eibrink, Marry M.

AU - Corssmit, Eleonora P.M.

AU - Kremer, Leontien C.M.

AU - Netea-Maier, Romana T.

AU - Van Der Pal, Heleen J.H.

AU - Peeters, Robin P.

AU - Plukker, John T.M.

AU - Ronckers, Cécile M.

AU - Van Santen, Hanneke M.

AU - Tissing, Wim J.E.

AU - Links, Thera P.

AU - Bocca, Gianni

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. Design: Survivors diagnosed between 1970 and 2013 at age #18 years, were included. Exclusion criteria were a follow-up ,5 years, attained age ,18 years, or diagnosis of DTC as a second malignant neoplasm (SMN). Controls were matched by age, sex, and socioeconomic status. Survivors and controls were asked to complete 3 questionnaires [Short-Form 36 (HRQoL), Multidimensional Fatigue Inventory 20 (fatigue), and Hospital Anxiety and Depression Scale (anxiety/depression)]. Survivors completed a thyroid cancer-specific HRQoL questionnaire. Results: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7).Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL. Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.

AB - Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. Design: Survivors diagnosed between 1970 and 2013 at age #18 years, were included. Exclusion criteria were a follow-up ,5 years, attained age ,18 years, or diagnosis of DTC as a second malignant neoplasm (SMN). Controls were matched by age, sex, and socioeconomic status. Survivors and controls were asked to complete 3 questionnaires [Short-Form 36 (HRQoL), Multidimensional Fatigue Inventory 20 (fatigue), and Hospital Anxiety and Depression Scale (anxiety/depression)]. Survivors completed a thyroid cancer-specific HRQoL questionnaire. Results: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7).Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL. Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.

UR - http://www.scopus.com/inward/record.url?scp=85017312344&partnerID=8YFLogxK

U2 - 10.1210/jc.2016-2246

DO - 10.1210/jc.2016-2246

M3 - Article

VL - 102

SP - 1218

EP - 1226

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -