Longitudinal Associations Between Inflammation and Depressive Symptoms in Chronic Dialysis Patients

Gertrud L. G. Haverkamp, Wim L. Loosman, Robbert W. Schouten, Casper F. M. Franssen, Ido P. Kema, Merel van Diepen, Friedo W. Dekker, Prataap K. Chandie Shaw, Yves F. C. Smets, Louis-Jean Vleming, Brigit C. van Jaarsveld, Adriaan Honig, Carl E. Siegert

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Abstract

OBJECTIVE: Patients undergoing chronic dialysis often display sustained elevations of inflammation markers and also have a high prevalence of depressive symptoms. Although multiple studies demonstrated cross-sectional associations between inflammation markers and depressive symptoms in this patient group, longitudinal associations have not been examined. We therefore investigated whether longitudinal associations exist between inflammation markers and depressive symptoms in chronic dialysis patients. METHODS: Data of three consecutive measurements of an observational, prospective cohort study among chronic dialysis patients were used. At baseline, 6-month, and 12-month follow-up, patients completed the Beck Depression Inventory, and inflammation markers (high-sensitivity C-reactive protein [HsCRP], interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor α) were measured. We examined cross-sectional associations between inflammation markers and depressive symptoms using linear regression models. The longitudinal association between inflammation and depressive symptoms was assessed using a linear mixed model analyses. RESULTS: A total of 513 patients were included. Cross-sectional associations were found between HsCRP and depressive symptoms at baseline (β = 0.9, confidence interval [CI] = 0.4-1.4) and 6-month follow-up (β = 1.1, CI = 0.3-2.0), and between IL-1β and depressive symptoms at 6-month follow-up (β = 1.3, CI = 0.8-1.8) and 12-month follow-up (β = 1.2, CI = 0.4-1.9). Inflammation makers (HsCRP, IL-6, IL-1β, IL-10, and tumor necrosis factor α) at baseline were not associated with depressive symptoms at follow-up and vice versa. CONCLUSIONS: We confirmed the presence of cross-sectional associations between inflammation markers and depressive symptoms in chronic dialysis patients, but with our longitudinal data, we found no longitudinal associations. This supports an associative instead of a causal relationship between inflammation and depressive symptoms.
LanguageEnglish
Pages74-80
JournalPsychosomatic Medicine
Volume81
Issue number1
DOIs
StatePublished - 2019

Cite this

Haverkamp, Gertrud L. G. ; Loosman, Wim L. ; Schouten, Robbert W. ; Franssen, Casper F. M. ; Kema, Ido P. ; van Diepen, Merel ; Dekker, Friedo W. ; Chandie Shaw, Prataap K. ; Smets, Yves F. C. ; Vleming, Louis-Jean ; van Jaarsveld, Brigit C. ; Honig, Adriaan ; Siegert, Carl E./ Longitudinal Associations Between Inflammation and Depressive Symptoms in Chronic Dialysis Patients. In: Psychosomatic Medicine. 2019 ; Vol. 81, No. 1. pp. 74-80
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title = "Longitudinal Associations Between Inflammation and Depressive Symptoms in Chronic Dialysis Patients",
abstract = "OBJECTIVE: Patients undergoing chronic dialysis often display sustained elevations of inflammation markers and also have a high prevalence of depressive symptoms. Although multiple studies demonstrated cross-sectional associations between inflammation markers and depressive symptoms in this patient group, longitudinal associations have not been examined. We therefore investigated whether longitudinal associations exist between inflammation markers and depressive symptoms in chronic dialysis patients. METHODS: Data of three consecutive measurements of an observational, prospective cohort study among chronic dialysis patients were used. At baseline, 6-month, and 12-month follow-up, patients completed the Beck Depression Inventory, and inflammation markers (high-sensitivity C-reactive protein [HsCRP], interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor α) were measured. We examined cross-sectional associations between inflammation markers and depressive symptoms using linear regression models. The longitudinal association between inflammation and depressive symptoms was assessed using a linear mixed model analyses. RESULTS: A total of 513 patients were included. Cross-sectional associations were found between HsCRP and depressive symptoms at baseline (β = 0.9, confidence interval [CI] = 0.4-1.4) and 6-month follow-up (β = 1.1, CI = 0.3-2.0), and between IL-1β and depressive symptoms at 6-month follow-up (β = 1.3, CI = 0.8-1.8) and 12-month follow-up (β = 1.2, CI = 0.4-1.9). Inflammation makers (HsCRP, IL-6, IL-1β, IL-10, and tumor necrosis factor α) at baseline were not associated with depressive symptoms at follow-up and vice versa. CONCLUSIONS: We confirmed the presence of cross-sectional associations between inflammation markers and depressive symptoms in chronic dialysis patients, but with our longitudinal data, we found no longitudinal associations. This supports an associative instead of a causal relationship between inflammation and depressive symptoms.",
author = "Haverkamp, {Gertrud L. G.} and Loosman, {Wim L.} and Schouten, {Robbert W.} and Franssen, {Casper F. M.} and Kema, {Ido P.} and {van Diepen}, Merel and Dekker, {Friedo W.} and {Chandie Shaw}, {Prataap K.} and Smets, {Yves F. C.} and Louis-Jean Vleming and {van Jaarsveld}, {Brigit C.} and Adriaan Honig and Siegert, {Carl E.}",
year = "2019",
doi = "10.1097/PSY.0000000000000649",
language = "English",
volume = "81",
pages = "74--80",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
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Haverkamp, GLG, Loosman, WL, Schouten, RW, Franssen, CFM, Kema, IP, van Diepen, M, Dekker, FW, Chandie Shaw, PK, Smets, YFC, Vleming, L-J, van Jaarsveld, BC, Honig, A & Siegert, CE 2019, 'Longitudinal Associations Between Inflammation and Depressive Symptoms in Chronic Dialysis Patients' Psychosomatic Medicine, vol. 81, no. 1, pp. 74-80. DOI: 10.1097/PSY.0000000000000649

Longitudinal Associations Between Inflammation and Depressive Symptoms in Chronic Dialysis Patients. / Haverkamp, Gertrud L. G.; Loosman, Wim L.; Schouten, Robbert W.; Franssen, Casper F. M.; Kema, Ido P.; van Diepen, Merel; Dekker, Friedo W.; Chandie Shaw, Prataap K.; Smets, Yves F. C.; Vleming, Louis-Jean; van Jaarsveld, Brigit C.; Honig, Adriaan; Siegert, Carl E.

In: Psychosomatic Medicine, Vol. 81, No. 1, 2019, p. 74-80.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Longitudinal Associations Between Inflammation and Depressive Symptoms in Chronic Dialysis Patients

AU - Haverkamp,Gertrud L. G.

AU - Loosman,Wim L.

AU - Schouten,Robbert W.

AU - Franssen,Casper F. M.

AU - Kema,Ido P.

AU - van Diepen,Merel

AU - Dekker,Friedo W.

AU - Chandie Shaw,Prataap K.

AU - Smets,Yves F. C.

AU - Vleming,Louis-Jean

AU - van Jaarsveld,Brigit C.

AU - Honig,Adriaan

AU - Siegert,Carl E.

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: Patients undergoing chronic dialysis often display sustained elevations of inflammation markers and also have a high prevalence of depressive symptoms. Although multiple studies demonstrated cross-sectional associations between inflammation markers and depressive symptoms in this patient group, longitudinal associations have not been examined. We therefore investigated whether longitudinal associations exist between inflammation markers and depressive symptoms in chronic dialysis patients. METHODS: Data of three consecutive measurements of an observational, prospective cohort study among chronic dialysis patients were used. At baseline, 6-month, and 12-month follow-up, patients completed the Beck Depression Inventory, and inflammation markers (high-sensitivity C-reactive protein [HsCRP], interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor α) were measured. We examined cross-sectional associations between inflammation markers and depressive symptoms using linear regression models. The longitudinal association between inflammation and depressive symptoms was assessed using a linear mixed model analyses. RESULTS: A total of 513 patients were included. Cross-sectional associations were found between HsCRP and depressive symptoms at baseline (β = 0.9, confidence interval [CI] = 0.4-1.4) and 6-month follow-up (β = 1.1, CI = 0.3-2.0), and between IL-1β and depressive symptoms at 6-month follow-up (β = 1.3, CI = 0.8-1.8) and 12-month follow-up (β = 1.2, CI = 0.4-1.9). Inflammation makers (HsCRP, IL-6, IL-1β, IL-10, and tumor necrosis factor α) at baseline were not associated with depressive symptoms at follow-up and vice versa. CONCLUSIONS: We confirmed the presence of cross-sectional associations between inflammation markers and depressive symptoms in chronic dialysis patients, but with our longitudinal data, we found no longitudinal associations. This supports an associative instead of a causal relationship between inflammation and depressive symptoms.

AB - OBJECTIVE: Patients undergoing chronic dialysis often display sustained elevations of inflammation markers and also have a high prevalence of depressive symptoms. Although multiple studies demonstrated cross-sectional associations between inflammation markers and depressive symptoms in this patient group, longitudinal associations have not been examined. We therefore investigated whether longitudinal associations exist between inflammation markers and depressive symptoms in chronic dialysis patients. METHODS: Data of three consecutive measurements of an observational, prospective cohort study among chronic dialysis patients were used. At baseline, 6-month, and 12-month follow-up, patients completed the Beck Depression Inventory, and inflammation markers (high-sensitivity C-reactive protein [HsCRP], interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor α) were measured. We examined cross-sectional associations between inflammation markers and depressive symptoms using linear regression models. The longitudinal association between inflammation and depressive symptoms was assessed using a linear mixed model analyses. RESULTS: A total of 513 patients were included. Cross-sectional associations were found between HsCRP and depressive symptoms at baseline (β = 0.9, confidence interval [CI] = 0.4-1.4) and 6-month follow-up (β = 1.1, CI = 0.3-2.0), and between IL-1β and depressive symptoms at 6-month follow-up (β = 1.3, CI = 0.8-1.8) and 12-month follow-up (β = 1.2, CI = 0.4-1.9). Inflammation makers (HsCRP, IL-6, IL-1β, IL-10, and tumor necrosis factor α) at baseline were not associated with depressive symptoms at follow-up and vice versa. CONCLUSIONS: We confirmed the presence of cross-sectional associations between inflammation markers and depressive symptoms in chronic dialysis patients, but with our longitudinal data, we found no longitudinal associations. This supports an associative instead of a causal relationship between inflammation and depressive symptoms.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30371633

U2 - 10.1097/PSY.0000000000000649

DO - 10.1097/PSY.0000000000000649

M3 - Article

VL - 81

SP - 74

EP - 80

JO - Psychosomatic Medicine

T2 - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

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