Longitudinal development of cancer-related fatigue and physical activity in childhood cancer patients

Elisabeth M. van Dijk-Lokkart, Lindsay M. H. Steur, Katja I. Braam, Margreet A. Veening, Jaap Huisman, Tim Takken, Marc Bierings, Johannes H. Merks, Marry M. van den Heuvel-Eibrink, Gertjan J. L. Kaspers, Eline van Dulmen-den Broeder, Raphaële R. L. van Litsenburg

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: Cancer-related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow-up time. This study evaluates cancer-related fatigue in children and its association with physical activity over a one-year time period. Methods: Sixty-eight children with cancer (7–18 years) were recruited during or within the first year after treatment. Physical activity (Actical activity monitor) and cancer-related fatigue (Pediatric Quality-of-Life Questionnaire Multidimensional Fatigue Scale (PedsQL-MFS), self- and parent- reports) were assessed at baseline, 4 months, and 12 months. PedsQL-MFS scores were compared with Dutch norms. Longitudinal association of cancer-related fatigue with physical activity was evaluated (No. NTR 1531). Results: Generally, PedsQL-MFS scores were worse than norms at baseline and 4 months, and recovered by 12 months except for the parent-proxy scores in adolescents. Younger children (≤12 years) self-reported comparable or better scores than norms. Physical activity generally improved over time, but patients mostly remained sedentary. During follow-up, increased physical activity was associated with less cancer-related fatigue. Conclusion: Cancer-related fatigue in children improves over time, and increased physical activity is associated with less cancer-related fatigue. Given the sedentary lifestyle of this population, the positive effect of physical activity on cancer-related fatigue, and the many other health benefits of an active lifestyle, it is important to stimulate physical activity in childhood cancer patients and survivors.
Original languageEnglish
Article numbere27949
JournalPediatric Blood and Cancer
Volume66
DOIs
Publication statusPublished - 1 Dec 2019

Cite this

@article{e159066234b346028b79f41b06c3c093,
title = "Longitudinal development of cancer-related fatigue and physical activity in childhood cancer patients",
abstract = "Purpose: Cancer-related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow-up time. This study evaluates cancer-related fatigue in children and its association with physical activity over a one-year time period. Methods: Sixty-eight children with cancer (7–18 years) were recruited during or within the first year after treatment. Physical activity (Actical activity monitor) and cancer-related fatigue (Pediatric Quality-of-Life Questionnaire Multidimensional Fatigue Scale (PedsQL-MFS), self- and parent- reports) were assessed at baseline, 4 months, and 12 months. PedsQL-MFS scores were compared with Dutch norms. Longitudinal association of cancer-related fatigue with physical activity was evaluated (No. NTR 1531). Results: Generally, PedsQL-MFS scores were worse than norms at baseline and 4 months, and recovered by 12 months except for the parent-proxy scores in adolescents. Younger children (≤12 years) self-reported comparable or better scores than norms. Physical activity generally improved over time, but patients mostly remained sedentary. During follow-up, increased physical activity was associated with less cancer-related fatigue. Conclusion: Cancer-related fatigue in children improves over time, and increased physical activity is associated with less cancer-related fatigue. Given the sedentary lifestyle of this population, the positive effect of physical activity on cancer-related fatigue, and the many other health benefits of an active lifestyle, it is important to stimulate physical activity in childhood cancer patients and survivors.",
author = "{van Dijk-Lokkart}, {Elisabeth M.} and Steur, {Lindsay M. H.} and Braam, {Katja I.} and Veening, {Margreet A.} and Jaap Huisman and Tim Takken and Marc Bierings and Merks, {Johannes H.} and {van den Heuvel-Eibrink}, {Marry M.} and Kaspers, {Gertjan J. L.} and {van Dulmen-den Broeder}, Eline and {van Litsenburg}, {Rapha{\"e}le R. L.}",
year = "2019",
month = "12",
day = "1",
doi = "10.1002/pbc.27949",
language = "English",
volume = "66",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",

}

Longitudinal development of cancer-related fatigue and physical activity in childhood cancer patients. / van Dijk-Lokkart, Elisabeth M.; Steur, Lindsay M. H.; Braam, Katja I.; Veening, Margreet A.; Huisman, Jaap; Takken, Tim; Bierings, Marc; Merks, Johannes H.; van den Heuvel-Eibrink, Marry M.; Kaspers, Gertjan J. L.; van Dulmen-den Broeder, Eline; van Litsenburg, Raphaële R. L.

In: Pediatric Blood and Cancer, Vol. 66, e27949, 01.12.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Longitudinal development of cancer-related fatigue and physical activity in childhood cancer patients

AU - van Dijk-Lokkart, Elisabeth M.

AU - Steur, Lindsay M. H.

AU - Braam, Katja I.

AU - Veening, Margreet A.

AU - Huisman, Jaap

AU - Takken, Tim

AU - Bierings, Marc

AU - Merks, Johannes H.

AU - van den Heuvel-Eibrink, Marry M.

AU - Kaspers, Gertjan J. L.

AU - van Dulmen-den Broeder, Eline

AU - van Litsenburg, Raphaële R. L.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose: Cancer-related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow-up time. This study evaluates cancer-related fatigue in children and its association with physical activity over a one-year time period. Methods: Sixty-eight children with cancer (7–18 years) were recruited during or within the first year after treatment. Physical activity (Actical activity monitor) and cancer-related fatigue (Pediatric Quality-of-Life Questionnaire Multidimensional Fatigue Scale (PedsQL-MFS), self- and parent- reports) were assessed at baseline, 4 months, and 12 months. PedsQL-MFS scores were compared with Dutch norms. Longitudinal association of cancer-related fatigue with physical activity was evaluated (No. NTR 1531). Results: Generally, PedsQL-MFS scores were worse than norms at baseline and 4 months, and recovered by 12 months except for the parent-proxy scores in adolescents. Younger children (≤12 years) self-reported comparable or better scores than norms. Physical activity generally improved over time, but patients mostly remained sedentary. During follow-up, increased physical activity was associated with less cancer-related fatigue. Conclusion: Cancer-related fatigue in children improves over time, and increased physical activity is associated with less cancer-related fatigue. Given the sedentary lifestyle of this population, the positive effect of physical activity on cancer-related fatigue, and the many other health benefits of an active lifestyle, it is important to stimulate physical activity in childhood cancer patients and survivors.

AB - Purpose: Cancer-related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow-up time. This study evaluates cancer-related fatigue in children and its association with physical activity over a one-year time period. Methods: Sixty-eight children with cancer (7–18 years) were recruited during or within the first year after treatment. Physical activity (Actical activity monitor) and cancer-related fatigue (Pediatric Quality-of-Life Questionnaire Multidimensional Fatigue Scale (PedsQL-MFS), self- and parent- reports) were assessed at baseline, 4 months, and 12 months. PedsQL-MFS scores were compared with Dutch norms. Longitudinal association of cancer-related fatigue with physical activity was evaluated (No. NTR 1531). Results: Generally, PedsQL-MFS scores were worse than norms at baseline and 4 months, and recovered by 12 months except for the parent-proxy scores in adolescents. Younger children (≤12 years) self-reported comparable or better scores than norms. Physical activity generally improved over time, but patients mostly remained sedentary. During follow-up, increased physical activity was associated with less cancer-related fatigue. Conclusion: Cancer-related fatigue in children improves over time, and increased physical activity is associated with less cancer-related fatigue. Given the sedentary lifestyle of this population, the positive effect of physical activity on cancer-related fatigue, and the many other health benefits of an active lifestyle, it is important to stimulate physical activity in childhood cancer patients and survivors.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070937423&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31436372

U2 - 10.1002/pbc.27949

DO - 10.1002/pbc.27949

M3 - Article

VL - 66

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

M1 - e27949

ER -