Longitudinal relation between blood pressure, antihypertensive use, and cerebral blood flow, using arterial spin labelling MRI

Jan Willem van Dalen*, Henri J.M.M. Mutsaerts, Jan Petr, Matthan W.A. Caan, Eric P.Moll van Charante, Bradley J. MacIntosh, Willem A. van Gool, Aart J. Nederveen, Edo Richard

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Consistent cerebral blood flow (CBF) is fundamental to brain function. Cerebral autoregulation ensures CBF stability. Chronic hypertension can lead to disrupted cerebral autoregulation in older people, potentially leading to blood pressure levels interfering with CBF. This study tested whether low BP and AHD use are associated with contemporaneous low CBF, and whether longitudinal change in BP is associated with change in CBF, using arterial spin labelling (ASL) MRI, in a prospective longitudinal cohort of 186 community-dwelling older individuals with hypertension (77 ± 3 years, 53% female), 125 (67%) of whom with 3-year follow-up. Diastolic blood pressure, systolic blood pressure, mean arterial pressure, and pulse pressure were assessed as blood pressure parameters. As additional cerebrovascular marker, we evaluated the ASL signal spatial coefficient of variation (ASL SCoV), a measure of ASL signal heterogeneity that may reflect cerebrovascular health. We found no associations between any of the blood pressure measures and concurrent CBF nor between changes in blood pressure measures and CBF over three-year follow-up. Antihypertensive use was associated with lower grey matter CBF (−5.49 ml/100 g/min, 95%CI = −10.7|−0.27, p = 0.04) and higher ASL SCoV (0.32 SD, 95%CI = 0.12|0.52, p = 0.002). These results warrant future research on the potential relations between antihypertensive use and cerebral perfusion.

Original languageEnglish
JournalJournal of Cerebral Blood Flow and Metabolism
Publication statusAccepted/In press - 2020

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